重组人α_1b型干扰素对宫颈人乳头瘤病毒16型母婴传播的阻断作用  

Study on the blocking effect of a recombinant human interferon alpha 1b on the perinatal transmission of HPV16 on cervix

作　　者：胡敏华[1] 张景华[1] 钱止维[1] 吴广芹 秦宇红[1] 王稚晖[1] 杨新科[1] 段淑敏[1] 侯云德 

机构地区：[1]北京天坛医院妇产科

出　　处：《北京医学》1998年第4期276-278,共3页Beijing Medical Journal

摘　　要：报告重组人α１ｂ型干扰素（简称干扰素）对宫颈人乳头瘤病毒１６型（ＨＰＶ－１６）母婴传播的阻断作用。４０例足月孕妇分为两组：治疗组２０例，用干扰素１０μｇ贴敷宫颈，隔日１次，共３次。另２０例为对照组。在治疗及临产前分别取宫颈洗液标本，再取其阴道分娩的新生儿咽拭子标本，用ＰＣＲ技术，检测其中ＨＰＶ－１６ＤＮＡ。结果：ＨＰＶ－１６母婴传播率在治疗组为２９．４％，对照组为８０％（Ｐ＜０．０２５）。A study of the blocking effect of a recombinant human interferon alpha 1b on the perinatal transmission of HPV16 on cervix was carried out in 40 cases of full term pregnant women and their neonates. The 40 pregnant women were divided into two groups. 20 cases in interferon group were treated with human recombinant interferon alpha 1b (produced by Changchun Institute of Biological Products) applied on cervix, 10μg every other day for three times; the rest 20 cases in control group without any treatment. Cervical specimens were obtained from all cases in two groups before treatment. Throat specimens were taken from all neonates after birth before feeding. HPV16 DNA in specimeans were detected by PCR method. The results indicated that HPV16 transmission rate in interferon group was 29.4% as compared with 80% in control group (P<0.025). It suggests that the recombinant human interferon alpha 1b applied locally insight be effective on blocking the transmission of HPV16 from mother's genital tract to the newborn baby at birth.

关 键 词：乳头瘤病毒16型 干扰素 母婴传播 宫颈 

分 类 号：R978.7[医药卫生—药品]