1287株下呼吸道感染G-杆菌的耐药监测  

Drug resistance surveillance of 1287 strains of gram-negative bacteria of lower respiratory tract

作　　者：罗昌明[1] 王项锋 孙嘉璐[1] 文杰[1] 

机构地区：[1]河南省周口市中心医院药品科,河南周口466000

出　　处：《中国医药导报》2009年第20期70-71,共2页China Medical Herald

摘　　要：目的:分析我院下吸道感染G-杆菌的菌群分布和耐药现状,为临床合理使用抗生素提供依据。方法:对我院2006～2008年呼吸内科病房下呼吸道感染G-杆菌患者送检的痰标本进行致病菌培养鉴定,按K-B琼脂扩散法进行常规药敏试验。结果:共分离G-杆菌1287株,铜绿假单胞菌307株(23.9%)居首位,大肠埃希菌271(21.1%)次之,肺炎克雷伯菌218株(16.9%)。铜绿假单胞菌对亚胺培南、美罗培南、头孢哌酮/舒巴坦、头孢吡肟较为敏感,嗜麦芽窄食单胞菌对多种抗生素的耐药率均较高。结论:下呼吸道感染G-杆菌的耐药性日益严重,应加强监测,有利于临床有效使用抗生素。Objective： To investigate the distribution and drug resistance of G- bacteria from lower respiratory tract in our hospital,and to give the reliable foundation for rational use of antibiotics in clinical treatment. Methods： We cultivated and identified the pathogens isolated from the sputum samples from patients with lower respiratory tract infection with G- bacteria in wards of respiratory diseases from 2006 to 2008 in our hospital. Antimicrobial susceptibility was tested by Kirby-Bane method. Results：A total of 1 287 strains of G-bacteria were isolated, which were Pseudomonas aeruginosa 307 strains （23.9%）,E.coli 271 strains （21.1%）,Klebsiella 218 strains （16.9%）in sequence,Imipenem,Meraopenem,Cefoperazone/Sulbaetam,Cefpine showed a very good antibacterial activity against Pseudomonas aeruginosa,Stenotrophomonas mal- tophiliam was resistant to almost all the clinical antibiotics.Conclusion：The drug resistance of G- bacteria from lower respiratory tract is serious insreasely.It is important and urgent to carry out surveillance of bacterial resistance for appropriate using of antibiotics effectively.

关 键 词：下呼吸道感染 G-杆菌 耐药监测 

分 类 号：R446.5[医药卫生—诊断学]