2型糖尿病患者血浆血栓素B2与6-酮-前列腺素1α的变化及其临床意义  

Plasma thromboxane B2 and 6-keto-prostaglandin-F1α in patients with type 2 diabetes mellitus

作　　者：李若男 林桂芳 

机构地区：[1]福建省老年医院内分泌科,福州350003

出　　处：《中国医药》2009年第7期517-519,共3页China Medicine

摘　　要：目的探讨2型糖尿病患者血浆血栓素B2（TXB2）、6-酮-前列腺素1α（6-keto—PGF1α）的变化及其在糖尿病大血管病变中的作用。方法采用放射免疫分析方法测定糖尿病组60例2型糖尿病患者（其中有大血管病变亚组43例，无大血管病变亚组17例）和31例对照组受试者的血浆TXB2、6-keto—PGF1α的浓度，并分析其相关性。结果血浆TXB2水平在糖尿病组有大血管病变亚组最高[（430．8±57．4）ng／L]；糖尿病无大血管病变亚组次之[（237．2±92．6）ng／L]；对照组最低[（80．8±33．8）．g／L]。血浆6-keto-PGF1α水平在糖尿病组有大血管病变亚组最低[（248．5±69．6）．g／L]；无大血管病变亚组次之[（327．9±64．5）ng／L]，对照组最高[（503．4±75．8）ng／L]。3组问分别进行方差齐性检验和两样本t检验，组间差异均具有统计学意义（均P〈0．05）。Pearson相关分析显示血浆TXB2与6-keto—PGF1α呈负相关（r=-0．829，P〈0．01）。结论TXB2、6-ke—to-PGF1α共同参与了2型糖尿病大血管病变的发生，可作为早期诊断和病情监测的指标。Objective To investigate the changes of plasma thromboxane B2 （TXB2 ） and 6-keto-prostaglan- din-F1α （6-keto-PGF1α ） in patients with type 2 diabetic mellitus and their roles in the pathogenesis of diabetic macroangiopathy. Methods Plasma levels of TXB2 and 6-keto-PGF1α were measured with RIA in 60 cases of type 2 diabetic patients（43 patients with and 17 without diabetic macroangiopathy）, with 31 cases of controls. Results Plasma levels of TXB2 in type 2 diabetic patients were significantly higher than those in controls. However, plasma levels of 6-keto-PGF1α , in type 2 diabetic patients were significantly lower than those in controls. Changes of both indexes were more significant in type 2 diabetic patients with macroangiopathy than those without macroangiopathy. Plasma levels of TXB2 showed negative correlation with 6-keto-PGF 1α . Conclusion TXB2 and 6-keto-PGF 1α may play important roles in the pathogenesis of diabetic macroangiopathy. Determination of TXB2 and 6-keto-PGF1α levels in type 2 diabetic patients may be useful for early detection of diabetic macroangiopathy.

关 键 词：2型糖尿病 大血管病变 血栓素B2 6-酮-前列腺素1α 

分 类 号：R587.1[医药卫生—内分泌]