3,13-酯基中乌头碱衍生物的合成及其杀虫活性的研究  

Synthesis and Insecticidal Activity of Derivants of 3,13-Ester Mesaconitine

作　　者：王晓东[1] 袁小红[1] 杨海君[1] 侯大斌[1] 王惠[1] 许源[1] 

机构地区：[1]西南科技大学生命科学与工程学院,四川绵阳621010

出　　处：《安徽农业科学》2009年第21期9830-9831,9848,共3页Journal of Anhui Agricultural Sciences

基　　金：国家十一五科技支撑计划重大专项课题(2006BAE01A01-12)

摘　　要：[目的]探讨中乌头碱及其衍生物的结构和杀虫活性的关系。[方法]通过酸酐或酰氯酯化合成中乌头碱的衍生物3-乙酰中乌头碱、3-丙酰中乌头碱、3-乙酰-13-苯甲酰中乌头碱和3-丙酰-13-苯甲酰中乌头碱,并对其进行杀虫活性测试。[结果]在浓度为500 mg/L时,中乌头碱对稻褐飞虱和苜蓿蚜的杀虫活性分别为50%和30%;3-乙酰中乌头碱、3-丙酰中乌头碱、3-乙酰-13-苯甲酰中乌头碱和3-丙酰-13-苯甲酰中乌头碱对苜蓿蚜的杀虫活性分别为40%、30%、30%和20%。[结论]中乌头碱羟基酯化后杀虫活性下降,3位羟基的存在对中乌头碱的杀虫活性的影响至关重要。[ Objective] The experiment aimed to explore the relation between structure of aconitine, aeonitine derivatives and insecticide. [ Method] The aconitine derivatives such as 3-acetyl mesaconitine, 3-propionyl mesaconitine, 3-acetyl-13-Benzoyl-mesaconitine and 3-propionyl-13-Benzoyl-mesaconitine were synthesized by mesaconitine with acetic anhydride or propionic anhydride and their insecticidal activities were also determined. [ Result] When the concentration was 500 mg/L, the insecticidal activities of mesaconitine against Nilaparvata legen and Aphis were 50% and 30% respectively while the insecticidal activities of 3-acetyl mesaconitine, 3-propionyl mesaconitine, 3-acetyl-13- Benzoyl-mesaconitine and 3-propionyl-13-Benzoyl-mesaconitine against Aphis rnedicagini were 40% ,30% ,30% and 20% respectively at 500 mg/L. [ Conclusion] After hydroxyl esterification, the insecticidal activity of mesaconitine was declined and the existence of hydroxyl at 3rd position in mesaconitine played very important influences on insecticidal activity.

关 键 词：中乌头碱 衍生物 结构 杀虫活性 

分 类 号：Q94[生物学—植物学]