Labrasol对兔眼刺激性评价  

Evaluation of Eye Irritation of Labrosol in Rabbits

作　　者：张欣华[1] 刘志东[1] 张伯礼[1] 舒乐新[1] 高秀梅[1] 柳占彪[1] 张远[1] 

机构地区：[1]天津中医药大学现代中药发现与制剂技术教育部工程研究中心,天津300193

出　　处：《医药导报》2009年第7期838-840,共3页Herald of Medicine

基　　金：国际科技合作项目(基金编号:2007DFC31670)

摘　　要：目的研究不同浓度Labrasol对兔眼的刺激性,确定其在眼用制剂中的安全范围。方法采用Draize评分标准,判断不同浓度Labrasol对兔眼刺激性的大小。结果0.5%,1.0%,1.5%,2.0%和3.0%的Labrasol对兔眼无刺激性,5%的Labrasol对兔眼有轻度刺激性。结论眼用制剂中较为安全的Labrasol浓度范围是0.5%～3%。Objective To explore the eye irritation of Labrasol in different concentrations in rabbits and determine its safety extent. Methods Use Draize＇s scale to investigate the eye irritation of Labrasol in rabbits. Results It was found that Labrasol at concentrations of 0.5% , 1.0% , 1.5% ,2.0% and 3.0% showed no eye irritations, while mild irritation at 5.0%. Conclusion The safety range of labrasol in an eye preparation was 0.5 % to 3.0%.

关 键 词：LABRASOL 眼刺激性 

分 类 号：R965.3[医药卫生—药理学]