BNP联合cTnI检测对充血性心力衰竭近期预后的评估价值  

Clinical Value of Combined Test of B-type Natriuretic Peptide and Cardiac Troponin I for the Prognosis of Patients with Congestive Heart Failure

作　　者：张洪[1] 赵施竹[1] 

机构地区：[1]鹤壁市鹤壁煤业集团总医院检验科

出　　处：《医学综述》2009年第14期2229-2231,共3页Medical Recapitulate

摘　　要：目的评价B型钠尿肽（BNP）联合心肌肌钙蛋白I（eTnI）对充血性心力衰竭的的预后的价值。方法测定84例CHF患者急诊时和出院时血BNP和cTnI等，观察并随访住院期间和出院后6个月内不良心脏事件的发生率、再住院率及病死率。结果NYHA心功能Ⅱ、Ⅲ、Ⅳ级患者的BNP分别为（539．2±201．7）、（739．2±208．7）、（1139．2±401．6）ng／L，心功能越差，BNP越高。心肌损伤与心功能程度之间是关联的。BNP≥500ng／L或cTnI≥50mg／L的患者住院期间与出院后6个月内不良心脏事件、再住院率和心源性病死率均高于BNP〈500ng／L或cTnI〈50mg／L的患者。结论联合BNP和cTnI可以更全面地评估CHF患者的危险程度和近期预后。Objective To evaluate the prognostic value of B-type natriuretic peptide （BNP） united with cardiac tropanin I （cTnI） in patients with congestive heart failure （CHF）. Methods The blood BNP and cTnI were determined in 84 patients with CHF at emergency department and leave hospital, and observated and followed up the occurrence of cardiac events rates in period of hospitalization and post-discharge for 6 months, and re-hospitalization and mortality. Results The BNP level of patients with NYHA cardiac function Ⅱ ,Ⅲ, Ⅳ were（539.2 ± 201.7 ）, （ 739.2 ±208.7 ）, （ 1139.2 ± 401.6 ） ng/L, respectively, the cardiac function was worse and BNP was higher. There was associated in myocardial injury and the degTee of cardiac function. The levels of blood BNP ≥500 ng/L or cTnI ≥50 mg/L of patients during hospitalization and post-discharge for 6 months adverse cardiac events, re-hospitalization rate and cardiac mortality were higher than those BNP 〈 500 ng/L or cTnI 〈 50 mg/L. Conclusion BNP combined with cTnI were able to assess the level of risks and short-term prognosis for patients with CHF.

关 键 词：B型钠尿肽 肌钙蛋白Ⅰ 心力衰竭 预后 

分 类 号：R541.6[医药卫生—心血管疾病]