老年原发性高血压患者血清Hcy、uAlb水平变化及叶酸等的干预作用  

Changes of serum Hcy and microalbuminuria levels in elderly patients with essential hypertension(EH) and effect of folic acid and so on

作　　者：王晓俐[1] 曲辉临 王晓玲[1] 李文华[1] 武春晓[1] 刘春[1] 

机构地区：[1]山东大学附属省立医院,济南250021 [2]山东电力中心医院

出　　处：《山东医药》2009年第23期9-11,共3页Shandong Medical Journal

基　　金：山东省保健医学科研基金资助项目(2007BZO4)

摘　　要：目的探讨老年原发性高血压(EH)患者血清同型半胱氨酸(Hcy)水平变化与肾损伤的相关性及叶酸等的干预作用。方法选择76例老年EH患者(EH组)及20例健康查体者(对照组),分别测定其血清Hcy、叶酸、维生素B12及尿微量白蛋白(Alb)、β2-微球蛋白(β2-MG)、尿免疫球蛋白(IgG)水平,分析其相关性;EH组连续口服叶酸、维生素B6及维生素B1216周后重复检测上述各参数。结果EH组血清Hcy及尿Alb水平均显著高于对照组(P<0.05、0.01),两者呈显著正相关(r=0.678,P<0.05);血叶酸、维生素B6及维生素B12均显著低于对照组(P<0.05);口服叶酸等治疗后EH组血清Hcy水平及尿Alb水平均显著低于治疗前。结论老年EH患者血清Hcy水平升高与其早期肾损伤有关,给予适量叶酸等干预治疗疗效确切。Objective To explore the relationship between serum homocysteine（Hcy） and mieroalbuminufia levels in elderly patients with essential hypertension （EH） and effects of folic acid and so on. Methods Seventy-six elderly patients with EH（ EH group） and 20 normal cases（ control group）were selected, serum levels of Hey, folie acid, VitB,2 and urinary albumin （uAlb）, β2-microglobulin （β2-MG） , urinary immunoglobulin （IgG） were measured, the relationship among which were analyzed. The EH group were treated with folic acid,VitB6 and VitB12 for 16 weeks, then the above-mentioned parameters were measured again. Results The serum Hcy and uAlb levels in EH group were higher than those in the control group （ P 〈 0.05,0.01 ） and showed positive relationship （ r = 0.678,P 〈 0.05）. While the serum levels of folic acid, VitB6 VitB12 in the EH group were lower than those in the control group （P 〈 0.05,0.01 ）. The serum Hcy and miemalbuminuria level in EH group decreased significantly after eombination treatment of folio acid, VitB6, VitB12. Condusion The serum Hcy levels in elderly patients with EH is closely related to the early renal injury, treatment by folic acid and so on is useful.

关 键 词：老年人 高血压 同型半胱氨酸 叶酸 

分 类 号：R544.1[医药卫生—心血管疾病]