阻塞性睡眠呼吸暂停低通气综合征及合并高血压患者8-异前列腺素F2α与C-反应蛋白的变化  

The changes of plasma 8-iso-prostaglandin F2α and serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome.

作　　者：李萍[1] 平芬[1] 孙洁静[1] 韩书芝[1] 李冲[1] 李琪[1] 

机构地区：[1]河北省人民医院老年病科,石家庄050051

出　　处：《中国综合临床》2009年第7期686-689,共4页Clinical Medicine of China

基　　金：河北省医学科学研究重点课题（07161）

摘　　要：目的检测血浆8-异前列腺素F2α（8-iso—PGF2α）及血清C-反应蛋白（CRP）水平在单纯阻塞性睡眠呼吸暂停低通气综合征（OSAHS）及合并高血压患者中的变化，探讨OSAHS的病理生理变化及合并高血压的发病机制。方法单纯OSAHS患者19例，OSAHS合并高血压患者21例，同期健康体检者20例，分别用ELISA法检测3组研究对象血浆8-iso—PGF2α及血清CRP的水平并进行比较。结果单纯OSAHS组血浆8-iso—PGF2α[（11．08±3．26）μg/L]及血清CRP[（1．75±0．82）mg／L]水平均高于健康对照组[分别为（7．49±2．10）μg/L与（0．52±0．26）mg／L，P均〈0．01]。OSAHS合并高血压患者血浆8-iso-PGF2α[（14．84±3．43）μg/L]及血清CRP[（3．13±1．06）mg／L]水平均高于单纯OSAHS患者及健康对照组（P均〈0．01）。结论OSAHS患者存在炎症及氧化应激水平升高，并参与OSAHS合并高血压的发生发展。Objective To investigate the plasma 8-iso-prostaglandin F2α （8-iso-PGF2α）and the serum C-reactive protein（CRP） levels in patients with obstructive sleep apnea-hypopnea syndrome（OSAHS） with and without hypertension（ OSAHS ＋ HT） ,and to explore the changes of pathophysiology in patients with OSAHS and the pathogenesis of OSAHS ＋ HT. Methods All observed subjects were divided into 3 groups ： control group （ n = 20）, OSAHS group（ n = 19）, OSAHS ＋ HT group （n = 21 ）. Plasma 8-iso-PGF2α and serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2α and serum CRP levels, were higher in OSAHS patients than those in control subjects [ （ 11.08 ±3.26 ）μg/L vs （ 7.49 ± 2.10 ） μg/L, P 〈 0.01 ; （ 1.75 ± 0.82）mg/L vs（0. 52 ±0.26）mg/L,P 〈0.01 ] ,and were higher in OSAHS ＋ HT group than those in control group [14.84 ±3.43） μg/L vs（11.08 ±3.26）μg/L,P 〈0.01 ;（3.13 ± 1.06）mg/L vs（1.75 ±0.82）mg/L,P 〈0.01 ]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased, which are involved in the development of OSAHS associated hypertension.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 原发性高血压 8-异前列腺素F2Α C-反应蛋白 氧化应激 炎症 

分 类 号：R766[医药卫生—耳鼻咽喉科]