磷酸咯萘啶在小鼠体内的药动学过程  

Study on Pharmaconkinetics of Pyronaridine in Mice

作　　者：曾品涛[1] 周慧[1] 韩玉梅[1] 傅善权[1] 郑一敏[1] 胥秀英[1] 

机构地区：[1]重庆理工大学化学与生物工程学院,重庆400050

出　　处：《重庆工学院学报（自然科学版）》2009年第7期48-50,共3页Journal of Chongqing Institute of Technology

基　　金：重庆理工大学与重庆通天药业有限公司合作项目(2008Q23)

摘　　要：研究磷酸咯萘啶在小鼠体内的药动学过程.小鼠一次性灌服磷酸咯萘啶后,用高效液相色谱法检测不同时间间隔血药浓度,计算药动学参数.小鼠一次灌胃1.56g.kg-1的磷酸咯萘啶后其药动学参数为:t1/2=(15.053±4.764)h,Tm ax=(6.072±0.834)h.结果表明,磷酸咯萘啶在小鼠体内药动学符合二房室开放模型,该方法准确可靠,操作简便,适用于药动学研究.This paper studies the pharmacokinetics of pyronaridine in mice and obtains pharmaeokinetic parameters. After a mouse is fed one time with pyronaridine, plasma concentrations are detected at different time point after ig single close of 1.56 g · kg^-1 with HPLC to calculate pharmacokinetic parameters. The pharmacokinetic parameters are determined after ig of pyronaridine （ 1.56 g · kg^-1） to mice. The main pharmacokinetic parameters of pyronaridine in mice were t1/2 = （15.053 ± 4.764） h, Tmax = （6.072 ± 0. 834） h. They all fit to the two-compartment open model. This experiment method satisfies the need for an accurate, sensitive, specific and convenient assay method in plasma for pharmaeokinefic studies of pyronaridine.

关 键 词：磷酸咯萘啶 药动学 高效液相色谱法 血药浓度 

分 类 号：R382.31[医药卫生—医学寄生虫学]