婴幼儿轮状病毒感染致肠道外损害的临床分析  

Clininal study of extraintestinal involvement after rotavirus infection in infants

作　　者：陈沫[1] 刘增香[1] 刘红兵[1] 

机构地区：[1]中山大学附属第五医院儿科,珠海519000

出　　处：《中国实用医药》2009年第18期13-14,共2页China Practical Medicine

摘　　要：目的探讨婴幼儿轮状病毒感染致肠道外损害的临床表现及实验室检查结果。方法对168例腹泻病患儿采用酶联免疫吸附试验(ELISA)方法检测大便中A组轮状病毒抗原,根据A组轮状病毒抗原检测结果,将其分为2组,即观察组(A组轮状病毒抗原阳性88例)与对照组(A组轮状病毒抗原阴性80例)对比两组的心肌酶、肝功、呼吸道感染、中枢神经系统损害状况。结果两组相比在年龄构成上无显著性差异(P>0.05)。心肌酶学指标明显升高(P<0.05),肝功酶学指标观察组比对照组升高,但无显著性差异(P>0.05),观察组呼吸道感染、中枢神经系统损害发生率明显高于对照组(P<0.05)。结论轮状病毒可导致肠管外多脏器损害,尤以心肌损害,呼吸道损害多见。Objective To study the clinical manifestations and laboratory results of extraintestinal organ damage after rotavirus infection in infants. Methods use ELISA to detect rotavirus in stool samples of patients. According to the result of stool samples, the patiens were divided into detected group （ RV positive group, 88 infants） and control group （RV negative group,80 infants）. The differences between these two groups of extraintestinal organ （ such as heart ,liver, respiratory tract, the central nervous system ） damaged were analyzed. Results There are no difference between detected group and control group in age. The concentrations of CK- MB was higher than in detected group （ P 〈 0. 05 ）. The concentrations of ALT in detected group were higher than in control group, butthere was no significant difference （ P 〉 0.05 ）. The incidence of respiratory tract infection and central nervous system involvement in detected group were significantly higher than those in control group（ P 〈0. 05）. Conclusions This study indicates that rotavirus can cause extraintestinal organ damage besides diarrhea, heart injury and respiratory tract injury are the most common.

关 键 词：肠炎 并发症 轮状病毒感染 心肌损伤 血液 

分 类 号：R725.1[医药卫生—儿科]