持续性皮下胰岛素输注对初诊2型糖尿病患者β细胞第一时相功能的影响  

Effect of continuous subcutaneous insulin infusion on the first-shase insulin secretion function of β cell in newly diagnosed type 2 diabete’s patients

作　　者：陈根本[1] 陈孺子 陈坚贞[1] 林权[1] 陈永松[2] 陈介东 

机构地区：[1]广东潮安县人民医院内科,515638 [2]汕头大学医学院第一附属医院内分泌科,515041 [3]揭西县棉湖华侨医院,515438

出　　处：《中国临床新医学》2009年第6期561-563,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广东省第三批科技计划项目(编号:2008146)

摘　　要：目的探讨持续性皮下胰岛素输注（CSII）对初诊2型糖尿病患者β细胞第一时相功能的影响。方法将42例初诊2型糖尿病患者随机分为治疗组和对照组，治疗组采用CSII，对照组仅皮下胰岛素注射，两组治疗前及治疗后2周采用IVGTT试验胰岛素曲线下面积进行疗效评估。结果治疗组2周后，对照组及治疗组与治疗前对比IVGTT试验胰岛素曲线下面积均显著升高，治疗组比较对照组IVGTT试验胰岛素曲线下面积升高更明显，差异有统计学意义（P〈0．01）。结论持续性皮下胰岛素输注能快速有效地提高初诊2型糖尿病患者B细胞第一时相胰岛素分泌功能。Objective To study the effects of （CSII） on the first -phase insulin secretion function of β cell in newly diagnosed type 2 diabetes patients. Methods Fourty - two newly diagnosed type 2 diabetes patients were randomly divided into therapy group and control group. The twenty- one patients in therapy group were treated with CSII,while 21 patients in control group were treated with insulin injection alone. Area under the curve of insulin （AUC） during IVGTT were compared between therapy group and control group. Results The AUC in control or therapy groups increased after week 2 of the treatment , and the AUC in therapy group were significiantly better than those in control group（P 〈 0. 01 ）. Conclusion CSII in the treatment of newly diagnosed diabetes is effective for raising the first phase insulin secretion funnction of β - cell.

关 键 词：持续性皮下胰岛素输注 糖尿病 Β细胞 

分 类 号：R587.1[医药卫生—内分泌]