阻塞性睡眠呼吸暂停低通气综合征合并冠心病患者间接胆红素和血脂的变化  

The Changes of Serum Indirect Bilirubin and Lipids Levels in Patients with OSAHS and OSAHS Associated CHD

作　　者：李萍[1] 王霞[1] 孙洁静[1] 苏力[1] 平芬[1] 李冲[1] 

机构地区：[1]河北省人民医院老年三科,河北石家庄050051

出　　处：《河北北方学院学报（医学版）》2009年第3期38-40,共3页Journal of Hebei North University:Medical Edition

摘　　要：目的:探讨血清间接胆红素(IBIL)及血脂在单纯阻塞性睡眠呼吸暂停低通气综合征(obstructivesleep apnea-hypopnea syndrome,OSAHS)及OSAHS合并冠心病患者中的变化,探讨OSAHS的病理生理变化及OSAHS合并冠心病的发病机制。方法:将研究对象分为正常对照组20例、OSAHS患者组31例、OS-AHS合并冠心病患者组19例,检测和比较3组患者血清IBIL及血脂的水平。结果:1.OSAHS患者组与正常对照组比较,血清IBIL、高密度脂蛋白胆固醇(HDL-C)明显降低(P<0.05),总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)明显升高(P<0.05,P<0.05,P<0.01),有统计学意义;OSAHS合并冠心病组与OSAHS患者组比较,血清IBIL、HDL-C亦明显降低(P<0.05),TC、TG、LDL-C明显升高(P<0.05,P<0.05,P<0.01),有统计学意义。2.OSAHS与OSAHS合并冠心病患者血清IBIL及血脂水平与反映睡眠呼吸暂停严重程度的指标明显相关。结论:OSAHS患者存在胆红素及脂质代谢异常,且在OSAHS合并冠心病患者中表现更为明显。Objectives：To investigat the serum indirect bilirubin（IBIL）and lipids levels in patients with obstructive sleep apnea-hypopnea syndrome（OSAHS） without compilcations and in those with obsturctive sleep apnea-hypopnea syndrome associated coronary heart disease（OSAHS＋ CHD）. To explore the change of pathophysiology in patients with OSAHS and the pathogenesis and predictor of OSAHS＋ CHD. Methods： All observed subjects were divided into 3 groups ： control subjects, OSAHS patients, OSAHS＋ CHD patients. Serum IBIL and lipids concentrations were measured and were compared among 3 groups. Results.. 1. The serum IBIL and high density lipoprotein cholesterol（HDL-C）levels of OSAHS patients were higher than that of control subjects （P〈0.05）. The serum total cholesterol （TC）, triglycerides （TG） and low density lipoprotein cholesterol（LDL-C） levels were apparently higher than that of normal control（P〈0.05, P〈0. 05, P〈0. 01 ） ; The serum IBIL and HDL-C levels of OSAHS ＋CHD patients were higher than that of OSAHS subjects（P〈0.05）. The serum TC,TG and LDL-C levels were apparently higher than that of OSAHS control（P〈0. 05, P〈0. 05 ,P〈0.01）. 2. The serum IBIL and lipids levels of OSAHS and OSAHS＋CHD patients were significantly correlated with the indexes reflecting the severity degree of obstructive sleep apnea. Conclusions.. There were abnormal metabolism of bilirubin and lipids in patients with OSAHS, and the changes in the patients with OSAHS＋CHD were more singnificant.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 冠心病 间接胆红素 血脂异常 

分 类 号：R563.9[医药卫生—呼吸系统] R446.111[医药卫生—内科学]