中国人六个群体ITI遗传多态性研究  

GENETIC POLYMORPHISM OF INTERALPHA-TRYPSIN INHIBITOR IN SIX CHINESE POPULATIONS

作　　者：吴谨[1] 侯一平[1] 李英碧[1] 苟清[1] 金泽明[1] 许云秀[1] 

机构地区：[1]华西医科大学法医学系生物学教研室

出　　处：《中华医学遗传学杂志》1998年第4期214-217,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金;纽约中华医学基金

摘　　要：目的概括了解间－α－胰蛋白酶抑制物（ＩＴＩ）基因频率在中国人群中的分布规律。方法应用聚丙烯酰胺凝胶等电聚焦，免疫印迹技术调查了中国６个群体ＩＴＩ遗传多态性。结果在吉林汉族、内蒙古蒙古族、大理白族和西藏藏族均观察到３个常见等位基因，ＩＴＩ＊１、ＩＴＩ＊２和ＩＴＩ＊３；广西壮族和广东汉族只检测出ＩＴＩ＊１和ＩＴＩ＊２两个等位基因，这些群体ＩＴＩ＊１基因频率介于０．５５００～０．７５２５，ＩＴＩ＊２基因频率介于０．２４７５～０．４３２２，ＩＴＩ＊３基因频率介于０．００３４～０．０７２９。结论研究发现。Objective To understand the distribution of allele frequencies of interalpha-trypsin inhibitor(ITI) in Chinese populations.Methods The polymorphism of this protein in six Chinese populations was investigated using isoelectric focusing followed by immunoblotting technique. Results Three common alleles, ITI*1, ITI*2, and ITI*3 were observed in four populations, namely Han living in Jilin, Mongol in Hailaer, Tibetan in Lasa, and Bai in Dali respectively. In other two populations, Zhuang in Guangxi and Han in Guangdong, only ITI*1 and ITI*2 were observed. For these populations, the frequency of ITI*1 ranges from 0.5500 to 0.7525; that of ITI*2 from 0.2475 to 0.4322; and that of ITI*3 from 0.0034 to 0.0729. Conclusion This study reveals that there is no parallel relationship between variation of allele frequencies and geographic differences.

关 键 词：群体遗传学 ITI 遗传多态性 胰蛋白酶抑制物 

分 类 号：Q346.5[生物学—遗传学] Q347