肌筋膜触发点疼痛的实验动物模型研究  

Development of Experimental Mouse Model of Myofascial Trigger Points

作　　者：姚明华[1] 黄强民[1] 

机构地区：[1]上海体育学院运动医学康复中心临床运动医学教研室,上海200438

出　　处：《中国运动医学杂志》2009年第4期415-418,共4页Chinese Journal of Sports Medicine

基　　金：上海市重点学科建设项目(S30802)资助

摘　　要：目的:根据肌筋膜触发点疼痛的形成机制建立实验动物模型。方法:36只雄性SD大鼠,随机分成3组,分别采用打击、离心运动和打击结合离心运动的方法进行肌筋膜触发点疼痛造模,以打击组非打击侧作为正常对照。造模组每周进行1次造模实验,连续4周。最后一次造模结束1周后,在局部解剖直视下观察局部紧张带,肌电自发电位和局部抽搐反应。结果:(1)可触及紧张带检查显示,正常对照组均为阴性。打击结合离心运动组的紧张带阳性率最高,为100%,显著高于正常对照组(P<0.01)。打击组和离心运动组阳性率分别为66.6%和33.3%,均显著高于正常对照组(P<0.01,P<0.05)。各造模组组间比较,以打击结合离心运动组阳性率最高(P<0.01)。(2)肌电图检查显示,正常对照组均为阴性。打击结合离心运动组肌电图阳性率最高,为91.7%,显著高于正常对照组(P<0.01)。打击组阳性率为58.3%,显著高于正常对照组(P<0.01)。离心运动组阳性率低,为16.7%,与正常对照组比较无显著性差异。各造模组组间比较,以打击结合离心运动组阳性率最高(P<0.05)。(3)抽搐反应结果显示,正常对照组肌肉内无局部抽搐反应,均为阴性。打击结合离心运动组抽搐反应阳性率最高,为100%,显著高于正常对照组(P<0.01)。打击组阳性率为50%,显著高于正常对照组(P<0.01)。离心运动组阳性率最低,为25%,与正常对照组比较无显著性差异(P>0.05)。各造模组组间比较,打击结合离心运动组阳性率最高(P<0.05)。结论:打击与打击结合离心运动的方法均可建立肌筋膜触发点疼痛的实验动物模型,但从临床特点上看,打击结合离心运动的方法更稳定可靠。重复同样强度的离心运动并不能有效激活触发点。Objective The purpose of the study was to develop an experimental animal model of myofascial trigger points. Methods Thirty six male mice were divided into three groups：group 1（n=12,right legs were crushed by a special devise）,group 2（n=12,underwent eccentric exercise）,and group 3（n=12,right legs were crushed plus eccentric exercise）. The left legs of the groups 1 and 3 served as control. The crushing in groups 1 and 3 was performed once a week for 4 weeks. Seven days after the last crushing,all mice were anatomized at the injured part for detecting the palpable taut band,recording myoelectrical auto-potential,and finding local twitch response. Experimental data from groups 1 and 3 were compared with that from group 2. Results Comparing to control group：（1）the incidence of palpable taut band was 100% in group 3（P〈0.01）,and 66.6% and 33.3% in group 2（P〈0.01）and in group 1（P〈0.05）, respectively. There was significant difference in the incidence of palpable taut band between group 1 and group 3（P 〈0.01）;（2）the incidence of myoelectrical auto-potential was 91.7% in group 3（P 〈0.01）,58.3% in group 1（P 〈0.01）, and 16.7% in group 2,respectively. Conclusion Mice in group 3 were more reliable and feasible as animal model of myofascial trigger points due to more similarity to the clinical manifestation.

关 键 词：肌筋膜触发点 打击 离心运动 紧张带 肌电图 抽搐反应 

分 类 号：R87[医药卫生—运动医学] R-332[医药卫生—临床医学]