黄蜀葵对实验性脂溢性脱发的影响初探  

Effect and mechanism of Abelmoschus manihot on the seborrheic alopecia of experimental rats

作　　者：陈方[1] 张生枝[1] 陈卫琴[1] 邹玲婷[1] 吕尚[1] 游兵华[1] 赖福记[1] 林卡莉[2] 

机构地区：[1]赣南医学院 [2]赣南医学院组织胚胎学教研室,江西赣州341000

出　　处：《赣南医学院学报》2009年第3期327-330,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：赣南医学院本科生科技创新课题(课题编号:2007201)

摘　　要：目的:观察黄蜀葵对实验性大鼠血清睾酮(T)、雌二醇(E2)、T/E2的调节作用及对毛发脱落的影响。方法:采用大鼠颈后皮下注射5 mg/(kg.d)剂量的丙酸睾丸酮造成脂脱模型,同时对实验组用黄蜀葵油煎剂进行治疗,并用山茶油作溶剂对照组,每天观察脱毛实验观察区脱毛情况,连续给药60 d后取血,用放射免疫法检测各组动物血清T、E2并计算出T/E2。结果:与正常对照组比较,模型组和溶剂对照组大鼠血清T明显升高,T/E2明显升高,单位面积脱毛数量明显增高(P<0.01);黄蜀葵油煎剂组分别与模型组、溶剂对照组比较,血清T明显降低,T/E2降低,单位面积脱毛数量减少(P<0.01)。结论:脂脱大鼠体内存在着明显的性激素(尤其是雄激素)失调,黄蜀葵可调节机体的性激素水平,使紊乱的T/E2趋于正常,预防毛发脱落。Objective： To investigate the regulation of Abelmoschus manihot on testosterone （T）, estradiol（ E2 ） and the proportion of T to E2 （T/E2 ） in rats blood and effect of losing hair. Methods： Seborrheic alopecia model was established by subcutaneous injection of T （5mg/kg · d）, Smearing Abelmeschus manihot （2ml/d in the prophase, 1 ml/d in the second half phase ） in the same time continuously for 60 days. Use camellia oil as solvent control group. T, E2 and T/E2 groups were detected by radioimmuneassay（PdA） method. Results： As compared with the normal group , the levels of T and T/E2 were higher. As compared with model group and solvent control group, the levels of T and T/E2 were lower in treated group. Conclusion： There is an obvious imbalance of sex hormones （ spodally androgenic hormones） in seborrheie alopecia. Abelmeschus manihot has the contraction of alopecin of hair. It can make the T/E2 to be stable.

关 键 词：脂溢性脱发 黄蜀葵 山茶油 雄激素 

分 类 号：R965[医药卫生—药理学]