增殖前期糖尿病视网膜病变氩激光联合导升明疗效观察  

Observation on the curative effect of argon laser photocoagulation combined with calcium dobesilate for treating pre-proliferation diabetic retinopathy

作　　者：张严卓[1] 于永斌[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院,150008

出　　处：《齐齐哈尔医学院学报》2009年第10期1157-1159,共3页Journal of Qiqihar Medical University

摘　　要：目的观察氩激光联合羟苯磺酸钙治疗增殖前期糖尿病视网膜病变的疗效。方法将45例,74眼确诊为增殖前期糖尿病视网膜病变的患者随机分为氩激光联合羟苯磺酸钙组和单纯氩激光组。分别给予全视网膜激光光凝。伴黄斑水肿者先行黄斑区格栅样光凝,再行全视网膜光凝。治疗后联合导升明(羟苯磺酸钙)组给予口服导升明(羟苯磺酸钙)3个月,单纯氩激光组术后除服用降糖类药物控制血糖外不服用其他药物。术后3个月比较两组视力及眼底变化情况,并进行统计学分析。结果1)视力,氩激光联合羟苯磺酸钙组术后视力提高27眼(71%)无变化7眼(18.4%)下降4眼(10.5%)。单纯氩激光组术后视力提高15眼(41.7%)无变化11眼(30.6%)下降10眼(27.8%)。2)眼底检查,氩激光联合羟苯磺酸钙组术后有效35眼(92.1%)无效3眼(7.9%)。单纯氩激光组术后有效26眼(72.2%)无效10眼(27.8%)。两组视力及眼底情况均有明显改善。其中氩激光联合羟苯磺酸钙组优于单纯氩激光组,且有统计学意义(P<0.05)。结论氩激光光凝是治疗增殖前期糖尿病视网膜病变安全有效的方法。导升明(羟苯磺酸钙)可能是一种相对安全和有效的治疗增殖前期糖尿病视网膜病变激光术后的药物。Objective To observe the curative effect of argon laser photocoagulation combined with calcium dobesilate for treating pre--proliferation diabetic retinopathy. Methods Fifty--two consecutive cases （74 eyes） with pre--proliferation diabetic retinopathy were enrolled. The patients were divided into two groups randomly. Calcium dobesilate were orally administrated for three months after argon laser coagulation in the experimentation group, and argon laser alone was used in control group. The two groups were given panreimal photocoagulation and mucular laser grid photocoagulation in advance with mucular edema. To follow 3 months after operation and then compared the change in vision and fundus of the 2 groups. The data were recorded and analyzed. Results 1 vision： there were 27 eyes （71%）which visual acuity was improved in the group of argon laser photocoagulation combined with calcium dobesilate, 7 eyes （18.4%） no change, 4 eyes （10. 5%） decreasing, there were 15eyes （41.7%）which visual acuity was improved in the group of argon laser alone, 11 eyes （30.6%）no change, 10 eyes （27.8%） decreasing. 2 fundus check and fundus fluorescein angiography： 35 eyes （92. 1%）were effective, 3 eyes （7.9 %）were ineffective in the group of argon laser photocoagulation combined with calcium dobesilate. 26 eyes （72.2 % ） were effective, 10 eyes （27.8 % ）were ineffective in the group of argon laser alone. The change of vision and fundus in 2 groups had significant difference. The clinical effects of argon laser pho- tocoagulation combined with calcium dobesilate were better than argon laser alone, there were significant difference between 2 groups （P 〈0.05）. Conclusions Argon laser photocoagulation is practicable and curative in the treatment of pre--proliferation diabetic retinopathy. Calcium dobesilate could be available for treatment combined of diabetic retinopathy.

关 键 词：氩激光 导升明(羟苯磺酸钙) 增殖前期糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌] R774.105[医药卫生—内科学]