慢性心力衰竭患者心脏再同步治疗疗效观察  

Follow-up of cardiac resynchronization therapy for patients with chronic heart failure

作　　者：王志军[1] 沈法荣[1] 陈建明[1] 凌锋[1] 陈旭娇[1] 钟诚[1] 金红锋[1] 何浪[1] 汤益明[1] 孙国建[1] 吴巧元[1] 

机构地区：[1]浙江医院心内科,杭州310013

出　　处：《中华心律失常学杂志》2009年第3期230-232,共3页Chinese Journal of Cardiac Arrhythmias

摘　　要：目的随访慢性心力衰竭患者心脏再同步治疗（CRT）的临床疗效。方法入选1999年至2008年行CRT的慢性心力衰竭患者，收集这些患者基线和最后一次临床资料。采集数据包括临床心功能评估，心脏超声学指标和体表心电图QRS时限宽度。结果95例患者行CRT治疗，分为早期组和近期组。早期组随访时间（57±17）个月，随访生存率为66．6％；近期组随访时间（18±10）个月，生存率为89．1％。两组患者CRT治疗后心功能显著提高，但自身状态下体表心电图QRS时限宽度变化差异无统计学意义。随访中患者药物治疗变化明显。结论中长期和短期随访均证实CRT治疗在一部分慢性心力衰竭患者中能提高心功能，但缺乏预测疗效的敏感指标。Objective This study was designed to evaluate the clinical outcome of cardiac resynchronization therapy（CRT） during short and mid-long term follow-up. Methods Consecutive patients treated with CRT between 1999 and 2008 were registered. Clinical information was collected from baseline and last follow- up. Clinical information included survival, clinical cardiac function, echocardiography parameters and QRS wave width from surface ECG. Results Ninety-five patients who were treated with CRT successfully were included. These patients were divided into two groups：those with only short term follow-up and those with mid-long term follow-up. In the short term follow-up group, survival was 89. 1% with follow-up of（ 18 ± 10 ）month（ median = 18 months）. Survival was 66. 6% in mid-long term group with follow-up of（ 57±17 ） months （ median = 54 moths）. While clinical cardiac function was significantly improved in both groups the intrinsic QRS wave width did not show significant change. Those patients＇ medical therapy for chronic heart failure has been changed dur- ing the period of follow-up. Conclusion CRT can improve clinical cardiac function in parts of patients with chronic heart failure and increased survival during mid-long term and short term follow-up. However, there remains a need for more sensitive indicators.

关 键 词：心脏再同步治疗 慢性心力衰竭 随访 

分 类 号：R541.6[医药卫生—心血管疾病]