蒲薏颗粒对化疗荷瘤小鼠的增效减毒及免疫功能的影响  

Study of Puyi Granule on Enhancing Effects of Chemotherapy and Reducing Toxicity and Immune Effect in Tumor-bearing Mice

作　　者：迟明艳[1] 黄勇[1] 王爱民[1] 兰燕宇[1] 王永林[1] 

机构地区：[1]贵阳医学院药学院,贵阳550004

出　　处：《中国现代应用药学》2009年第6期436-439,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：贵州省中药现代化科技产业专项基金项目[黔科合中药专字(2004)08号]

摘　　要：目的研究蒲薏颗粒对荷瘤小鼠化疗增效、减毒及免疫调节作用。方法建立小鼠恶性肿瘤转实体瘤模型,观察蒲薏颗粒与化疗药物合用对瘤体重量、血液白细胞(WBC)数、骨髓有核细胞数的影响;对肿瘤坏死因子(TNF-a)的影响以及对荷瘤小鼠免疫功能的影响。结果蒲薏颗粒能增强化疗药物抑瘤作用、拮抗化疗药物对WBC及骨髓有核细胞的抑制;提高荷瘤小鼠TNF-a含量;增强免疫功能。结论蒲薏颗粒对荷瘤小鼠具有化疗增效、减毒及免疫增强的作用。OBJECTIVE To investigate the immunization in mice implanted tumor. METHODS effects of Puyi granule for the Build up the mice models with chemotherapy, toxicity-reducing and malignant tumor transfered by ascites tumor, and observe the effect on tumor weight, blood WBC and bone marrow nucleated cells when combined use Puyi granule and chemotherapeutic. Measure tumor necrosis factor and observe the immune effect in the mice models. RESULTS Puyi granule can strengthen antitumor activity of chemotherapeutic, antagonize the inhibition of chemotherapeutic to WBC and bone marrow nucleated cell, improve tumor necrosis factor, also can enhance immune function. CONCLUSION Puyi granule can increase the chemotherapeutic effect, reduce toxin, and enhance immune function.

关 键 词：蒲薏颗粒 化疗 增效减毒 免疫调节 

分 类 号：R285.5[医药卫生—中药学]