黄芪对快速加减压大鼠急性肾损伤的保护作用  

Protective effects and mechanism of astragalus preparation on renal damage induced by fast compression and decompression in rats

作　　者：林淑华[1] 滕舰[1] 袁东[1] 孙崇启 

机构地区：[1]烟台市烟台山医院,山东省烟台264001 [2]烟台市经济开发区医院

出　　处：《中华航海医学与高气压医学杂志》2009年第3期148-150,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨黄芪对快速加减压大鼠急性肾损伤的保护作用及其机制。方法选用健康雄性SD大鼠54只，随机分为3组：（1）对照组（C组）18只，不进行任何处理；（2）快速加减压组（F组）18只，进行快速加减压处理；（3）黄芪预处理组（H组）18只，快速加减压前用10g／kg黄芪注射液灌胃。分别于快速加减压1、2、12h后检测血清肌酐（SCr）、肾组织SOD、肾组织丙二醛（MDA），观察快速加减压1h后肾组织的病理变化。结果F组和H组每个时间点SCr水平高于C组（P〈0．01），组内2h SCr水平均高于1、12h（P〈0．01）；H组SCr水平在相应时点低于F组（P〈0．01）；F组和H组每个时间点肾组织MDA水平高于C组（P〈0．01），组内2h水平均高于1、12h（P〈0．01）；H组在相应时点低于F组（P〈0．01）；F组和H组每个时间点肾组织SOD水平低于C组（P〈0．01），组内2h水平均低于1、12h（P〈0．01），H组在相应时点高于F组（P〈0．01）。结论黄苠对快速加减压后肾脏损伤具有保护功能，其机制可能是减少了体内MAD的产生和SOD的消耗。Objective To investigate protective effects and mechanism of astragalus preparation on renal damage induced by fast compression and decompression in rats. Methods 54 SD rats were randomly divided into 3 groups, i.e. the control group consisting of 18 rats without any treatment; the fast compression and decompression group （fast group） consisting of the same number of rats were exposed to fast compression and decompression; The astragalus experimental group of 18 rats were orally administrated with astragalus preparation （10 g/kg） before and after fast compression and decompression. SCr, SOD and MDA in the renal tissue were measured 1 h, 2 h and 12 h following fast compression and decompression. Pathological changes in the renal tissue were observed 1 h after fast compression and decompression. Results SCr and MDA in renal tissue in the fast and experimental groups were higher than that of the control group （P 〈 0.01 ）. SCr and MDA in the renal tissue in the experimental group were lower than those of the fast group （ P 〈 0.01 ）. SCr and MDA in the renal tissue after 2 h were higher after 1 and 12 h within group （P 〈0.01 ） ; SOD in the renal tissue in fast and experimental groups was lower than that of the control group （P 〈 0.01 ）. SOD in the renal tissue for the experimental group was higher than that of the fast group at all time points（P 〈 0.01 ）. SOl） in the renal tissue after 2 h was lower than the 1 and 12 h within group （P 〈 0.01 ）. Conclusions Astragalus preparation might be effective against renal damage following fast compression and decompression. Its mechanism might be due to reduced production of MAD and consumption of SOD.

关 键 词：快速加减压 血清肌酐 超氧化物歧化酶 丙二醛 黄芪 

分 类 号：R686[医药卫生—骨科学]