不同分型的慢性前列腺炎对精液质量的影响  

Effect of Semen Quality in the Different Type of Chronic Prostatitis

作　　者：袁润强[1] 杨志钊[2] 郑少斌[1] 丘少鹏[3] 李新民[2] 周华扩[2] 石映江[2] 

机构地区：[1]南方医科大学附属南方医院泌尿外科,广州510000 [2]中山市人民医院泌尿外科 [3]中山大学附属第一医院泌尿外科

出　　处：《临床泌尿外科杂志》2009年第7期522-526,共5页Journal of Clinical Urology

基　　金：中山市研究基金资助(编号20082A046)

摘　　要：目的:研究不同分型的慢性前列腺炎对精液质量恶化的影响。方法:根据目前存在感染和(或)针对前列腺的自身细胞免疫反应情况,将49例慢性前列腺炎患者进行分组。健康正常的个体作为对照组。检查包括精子密度、死亡率、形态、前列腺与精囊标记物、抗精浆抗体、白细胞计数与伴随的炎症前细胞因子。结果:最严重的畸形见于无明显感染而有针对前列腺的自身细胞免疫患者。此外,在此类患者的精浆中检测到炎症前细胞因子水平显著升高。结论:伴有针对前列腺的自身细胞免疫反应的慢性前列腺炎患者的精液质量参数有重要改变,并因此而引起不育。Objective： To investigate whether different type of chronic prostatitis could have a deleterious effect on semen quality. Methods：Forty nine patients diagnosed as suffering from chronic prostatitis were included and divided into groups according to the presence of infection and/or cellular autoimmune response against prostate antigens. Healthy normal individuals were included as controls. Measurements for sperm concentration, motility, morphology, prostate and seminal vesicle markers, antisperm antibodies, white blood cells and pro inflammatory cytokines were performed accordingly. Results：The most severe abnormalities were found in patients with no evident infection and an autoimmune response against prostate antigens. Moreover, significantly increased levels of pro inflammatory cytokines were detected in seminal plasma from these patients. Conclusions： This study shows that chronic prostatitis patients with cellular autoimmune response to prostate antigens present important alterations in their semen quality parameters and may affect male fertility.

关 键 词：前列腺炎 自身细胞免疫 精液质量 

分 类 号：R697[医药卫生—泌尿科学]