磁共振成像与血管内超声识别兔腹主动脉易损斑块的对比研究  

The evaluation of vulnerable atherosclerotic plaques in rabbit abdominal aorta by a magnetic resonance imaging versus an invasive intravascular ultrasound method

作　　者：方红城[1] 苏又苏[1] 庞红[1] 吴京兰[1] 付剑云[1] 谢培益[1] 陈菲[1] 李明华[1] 

机构地区：[1]广东医学院附属深圳市第六人民医院心内科,广东深圳518052

出　　处：《临床心血管病杂志》2009年第7期540-544,共5页Journal of Clinical Cardiology

基　　金：深圳市科技局项目(No:200803177);深圳市南山区科技局项目(No:科2006174-6)

摘　　要：目的:探讨磁共振成像(MRI)和血管内超声(IVUS)识别兔腹主动脉易损斑块(VP)的价值。方法:20只雄性新西兰大白兔给以球囊拉伤腹主动脉加高脂饮食8周,建立兔腹主动脉VP模型。15只兔成功建立VP模型后分别进行MRI扫描和IVUS检查、病理组织学检查。结果:MRI和IVUS识别兔动脉粥样硬化VP的敏感性分别为83.8%和89.2%,特异性为90.6%和90.6%。MRI对VP检测阳性率结果与IVUS比较,差异无统计学意义(χ2=0.10,P>0.05)。结论:MRI与IVUS相似,对识别兔腹主动脉VP有较好的价值。Objective： To investigate the diagnosis on the vulnerable atherosclerotic plaques（VP） in rabbit＇s abdominal aorta between the magnetic resonance imaging（MRI） and invasive intravascular ultrasound （IVUS）. Methods： To establish VP model, twenty male New Zealand white rabbits were fed with hyperlipid diet for 8 weeks ,after their abdominal arteries being injured by balloons. MR imaging, IVUS and histopathologic exam were performed on 15 rabbits who had established VP model successfully. Results：Compacted with histopathologic findings, the sensitivity and the specificity of VP was 83.8 % and 90.6 % on MRI respectly and that on IVUS was 89.2% and 90.6% respectly. However there was no significance difference between these two methods （x^2 = 0.10,P〉0. 05）. Conclusion..MRI can play a key role in diagnosis of the VP in rabbit＇s abdominal aorta.

关 键 词：动脉粥样硬化 磁共振成像 超声检查 介入性 兔 

分 类 号：R543.1[医药卫生—心血管疾病]