螺旋CT双期增强扫描测定肾小球滤过率  

Glomerular filtration rate measurement using dual-phase helical CT

作　　者：徐亮[1] 钟建国[2] 龚建平[1] 张伟[1] 朱雪明[3] 张平[3] 宦坚[1] 王建玲[1] 钱铭辉[1] 单玉喜[4] 

机构地区：[1]苏州大学附属第二医院放射科,215004 [2]浙江省人民医院放射科 [3]苏州大学附属第二医院检验科,215004 [4]苏州大学附属第二医院泌尿外科,215004

出　　处：《江苏医药》2009年第7期752-754,共3页Jiangsu Medical Journal

基　　金：苏州市社会发展基金(SZD0765)

摘　　要：目的研究螺旋CT双期增强扫描测定肾小球滤过率(GFR)的方法及其准确性,评估UroCARE软件计算GFR的可靠性。方法选择25例无急性肾功能障碍的成年患者,CT检查包括腹部平扫和双期增强扫描(动脉期、门静脉期),同时在动脉期前与两期之间各插入一组同层动态扫描。应用UroCARE软件计算GFR,以血清半胱氨酸蛋白酶抑制剂C(CystatinC)测定的GFR作为对照指标。结果两种方法测定的GFR相关性良好,r=0.799,y=39.0977+0.6083x。结论螺旋CT双期增强扫描并应用UroCARE软件可以较准确地测定GFR,具有一定的临床应用前景。Objective To investigate the technique and accuracy of dual-phase helical CT for measuring glomerular filtration rate （GFR）, and evaluate the reliability of software UroCARE for determining GFR. Methods Twenty-five adult patients without acute renal disorder were included in this study. Each patient underwent CT for clinical indications. The CT protocol consisted of a plain examination and two contrast material-enhanced examinations in the arterial and portovenous＇ phase. Seven dynamic scans were obtained before arterial phase, while four scans obtained between arterial and portovenous phase with reduced tube current every 2 seconds to obtain sufficient function data. CT clearance was calculated by software UroCARE. As a reference, cystatin C was determined in 25 blood specimens. Results Linear regression analysis showed that GFR of two groups was well correlated. The correlation coefficient of whole kidney was 0. 799 and a regression line of y： 39. 0977 ＋0. 6083x. Conclusion GFR can be measured accurately with minimally extended dual-phase CT for patients without acute renal disorder. It is reliable in clinical practice to use the software UroCARE for determining GFR.

关 键 词：肾小球滤过率 双期扫描 计算机体层摄影术 

分 类 号：R816[医药卫生—放射医学]