阳春胶囊的药理作用及其初步机理的研究  

Studies on pharmacological action of Yangchun Capsule and its preliminary mechanism of action

作　　者：王四旺[1] 谢艳华[1] 王思功 朱玲珍[1] 

机构地区：[1]第四军医大学药物研究所,西安710033 [2]洛阳医学专科学校药剂科

出　　处：《第四军医大学学报》1998年第4期402-405,共4页Journal of the Fourth Military Medical University

摘　　要：观察阳春胶囊（YCC）药理作用及其初步作用机理．方法：采用手术或药物诱发技术复制去势、“肾阳虚”及蛋清性关节炎等动物模型进行实验．结果：①1．5g／kgYCC能明显升高去势和肾阳虚小鼠血清睾酮含量和肾上腺、精囊腺重量（P＜0．05或0．01），对胸腺重量则明显抑制（P＜0．05或0．01）；②能显著抑制正常大鼠蛋清性踝关节肿胀；对去肾上腺大鼠蛋清性踝关节肿胀除6h大剂量组外则无影响（P＞0．05）；③1．5g／kgYCC和20IU／只ACTH均显著升高正常大鼠血浆皮质醇含量（P＜0．01），而30mg／kg戊巴比妥钠能有效对抗YCC的这一作用；④1．5g／kgYCC能提高正常和肾阳虚小鼠巨噬细胞吞噬百分率和吞噬指数（P＜0．01），但对血清溶血素的形成正常小鼠无改变（P＞0．05），而肾阳虚小鼠则有明显促进作用（P＜0．01）．结论：①YCC表现出明显雄性激素样作用，其机制可能与YCC兴奋下丘脑-垂体-肾上腺皮质轴，引起肾上腺皮质激素分泌有关；②对正常小鼠具有抗炎和升高血浆皮质醇含量及增强免疫功能作用．Aim: To explore the pharmacological action ofYangchun Capsule (YCC) and its preliminary mechanism ofaction. Methods: The models of eunuchized mice andnephroyangpenia mice and tumefaction of rats' ankle jointwere prepared by operation or medicine, and then observethe therapy action of YCC was observed. Results: ①Aftertreated by ig YCC 1. 5 g·kg(-1) per day for 12 d, boththe eunuchized mice and the nephroyangpenia mice, theweight of adrenal gland and seminal vesicle gland were increased, and the content of testosterone increased as well(P<0.05 or P<0.01), but the weight of thymus were reduced (P<0. 05 or P<0.01); ②YCC was restrained thetumefaction of normal rats' ankle joint by egg white, but itdid no effects on rats whose adrenal glands were extripatedexcept the large dosage (1. 5 g·kg(-1)) being given for 6 h;③Both the dosage of 1.5 g·kg(-1) and 20 IU ACTH per ratwere given, contents of the plasma cortisol were increased(P<0.01), but this action was antagonized by pentobarbital sodium for 30 mg·kg(-1);④Both normal and modelmice, the macrophages' percentage and index of phagocytosis were improved by ig YCC 1. 5 g·kg(-1)(P<0. 01). Thisdosage did no effects on hemolysm formation to normal mice(P>0. 05), but it did to nephroyangpenia mice (P<0. 01 ).Conclusion:①YCC expresses the same action as androgen,its mechanism of action may be explained by that YCC couldexcite hypothalamus-pituitary-adrenco axis, then causesecretion of adrenocortical hormone;②YCC has some function of anti-inflammation, increasing content of plasma cortisol and improving immunological function to normal mice.

关 键 词：阳春胶囊 中药 生殖内分泌 药理 实验药理 

分 类 号：R285.5[医药卫生—中药学] R286.923[医药卫生—中医学]