葛根素对小鼠脑微循环血流量的影响  

Effect of Puerarin on Cerebral Microcirculatory Blood Flow in Mice

作　　者：李定格[1] 王世军[1] 李以菊 荆雪梅[1] 姬广臣[1] 

机构地区：[1]山东中医药大学

出　　处：《微循环学杂志》1998年第2期8-9,共2页Chinese Journal of Microcirculation

基　　金：山东省自然科学基金

摘　　要：为了观察静脉注射葛根素对小鼠脑微循环的影响，应用ＪＩ２００型激光微循环动态分析仪直接记录脑微循环血流量的变化。结果表明，正常小鼠静脉注射葛根素（０．２ｍｇ／ｋｇ）３ｍｉｎ后，脑微循环血流量显著增加（Ｐ＜０．０５），且持续３０ｍｉｎ；提高葛根素剂量（２ｍｇ／ｋｇ），其效应加强且持续６０ｍｉｎ。高分子右旋糖酐所致脑微循环障碍小鼠静脉注射葛根素后，脑微循环血流量有改善，但作用较弱。结果提示，葛根素可增加正常小鼠脑微循环血流量。The effect of puerarin on cerebral microcirculatory blood flow(CMBF) were observed in mice. Method: using closed cranial windows method and Laser microcirculation dynamic analyzer record the cerebral microcirculatory blood flow. Results: In normal mice, intravenous injection of Puerarin can significantly increase the cerebral microcirculatory blood flow at the 3rd minutes after the injection and the increase may last for 30 minutes. When the dosage of Puerain increase, its effect is also strengthened. To the mice of cerebral microcircultion disturbance by HMWD, the effect of Puerain on CMBF are not stronger than normal mice. The results indicate that Puerarin can increase the CMBF, improve cerebral microcirculation.

关 键 词：葛根素 小鼠 微循环 脑血管 血流量 

分 类 号：R285.5[医药卫生—中药学]