多囊卵巢综合征患者血清sICAM-1水平与性激素及肥胖的相关性研究  

The Associativity between Serum sICAM-1 and Sex-hormone,Obsess in PCOS Patients

作　　者：蒋凤艳[1] 胡芸[1] 黄卡立[1] 韩玲[1] 黄一华[1] 

机构地区：[1]广西医科大学第一附属医院,广西南宁530021

出　　处：《实用妇产科杂志》2009年第7期402-404,共3页Journal of Practical Obstetrics and Gynecology

基　　金：广西科技厅自然科学基金课题(桂科基NO:0663025);广西教育厅科研课题(项目编号:200510024)

摘　　要：目的:探讨多囊卵巢综合征(PCOS)患者血清sICAM-1水平与性激素及肥胖的相关性,为PCOS患者心血管疾病的防治提供理论依据。方法:以体重指数(BMI)≥24kg/m2或腰臀比(WHR)≥0.8为肥胖标准,将96例PCOS患者分为肥胖组和非肥胖组。测量其身高(m)、体重(kg)、腰围(cm)、臀围(cm)和测定性激素水平以及sICAM-1水平,并将sICAM-1与所测临床指标进行多因素分析。结果:肥胖组血清sICAM-1水平高于非肥胖组(P<0.05),多因素分析显示血清sICAM-1水平与年龄、BMI、WHR、睾酮呈正相关。结论:PCOS患者sICAM-1水平随着年龄、BMI、WHR和睾酮水平增高而升高。PCOS患者血清sICAM-1水平与肥胖尤其是中心性肥胖有密切联系。应积极治疗和监测PCOS患者,以防止和减少其心血管疾病的发生发展。Objective：To research plasma soluble intercellular adnesion molecule-1 （sICAM-1） concentration in pa- tient with Polycystic Ovarian Syndrome （PCOS）, and to provide the basis for prevention and treatment of cardiovas： cular disease in these women. Methods：According to BMI≥24 kg/m2 or WHR≥0.8, all the PCOS subjects were divided into obese group and non-obese group. All subjects were measured height （m）, weight （kg）, waist circum- ference （cm）, hip circumference （cm） ,sex hormone level, and the level of sICAM-1. The multiple linear regression analysis was done between sICAM-1 and clinical indexes above. Results：The serum sICAM-1 level in obese group was higher than the non-obese group （ P〈 0.05）; the serum sICAM-1 level had positive correlation with age, BMI, WHR,and serum testosterone by multiplicity analysis. Concluslons： The serum sICAM-1 level of PCOS patients is much higher, corresponding to higher BMI, WHR and serum testosterone level. The sICAM-1 associated with obese, especially with central obese. So we must monitor PCOS patients closely, especial PCOS central obese patients, in order to prevent cardiovascular diseases.

关 键 词：多囊卵巢综合征 SICAM-1 肥胖 性激素 

分 类 号：R711.75[医药卫生—妇产科学]