紫外线激活纤溶系统中组胺的上调作用  

A study of role of histamine in up-regulation of fibrinolytic activity by full-spectrum ultraviolet irradiation

作　　者：丁立新[1] 李祚秀[1] 李淑芹[1] 刘竹南[1] 杨永辉[1] 

机构地区：[1]第四军医大学唐都医院理疗康复科,西安710038

出　　处：《第四军医大学学报》1998年第4期370-372,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金!39400124

摘　　要：探讨组织胺在紫外线（UV）激活纤溶系统（FS）效应中的作用．方法：将14只健康成年犬随机分成3组，UV组和UV＋bufrolin（组织胺释放抑制剂）组（各5只犬）行全光谱UV20cm×20cm，447．72mJ／cm2照射胸腹部1次，UV＋bufrolin组对UV辐射区皮肤预先局部给予bufrolin；空白组（4只犬）不行UV照射，作对照用．观察3组UV照射后48h内辐射区皮肤组织内组织胺水平及血纤溶酶原激活物（PA）活性的动态变化．结果：UV组在UV照后3h血PA活性明显增高，照后9h达其峰值；辐射区皮肤组织组织胺浓度UV照后9h明显升高，其峰值约在UV照后15h；局部皮肤预先给予bufrolin后，UV＋bufrolin组UV照射区皮肤组织内组织胺浓度升高不明显，血PA活性仍明显增高．结论：组织胺可能并不参与UV上调FS活性的作用．Aim: To study possible role of histamine in upregulation of fibrionlytic system (FS) by full-spectrum ultraviolet (UV) radiation. Methods: Fourteen normal healthyadult dogs were randomly divided into 3 groups. Both UVand UV+bufrolin-groups (each n=5) were treated by single 20 cm×20 cm, 447. 72 mJ/cm2 full-spectrum UV radiation on thoracoabdominal skins, UV + bufrolin-group wereadministered 400 mg bufrolin into local skins to be irradiated immediately before UV radiation,and control-group (n=4 ) got neither UV- nor bufrolin-treatment. During 48 hpostirradiation histamine concentrations in suction blisterfluid from UV-irradiated skins and plasma tissue plasminogen activator (PA) activity were assayed dynamically. Results: Plasma PA activity of UV-group significantly increased at 3 h postirradiation (P<0.01), with peak at 9 hafter irradiation;histamine levels in suction blisters markedly increased at 9 h postirradiation (P<0.01), with peaklevels at 15 h after irradiation,and relationship between histamine levels and PA activity was not noted (P>0. 05). InUV + bufrolin-group, however, plasma PA activity timecourse had the same characteristic as UV-group (P >0. 05), although histamine levels had no marked changesbecause of bufrolin administrations pre-UV irradiation.Conclusion: Histamine might not be involved in up-regulation of fibrinolytic activity by full-spectrum UV irradiation.

关 键 词：紫外线 纤溶系统 组织胺 犬 

分 类 号：R454.2[医药卫生—治疗学]