外周血干细胞因子及其受体表达与血压水平的关系  

Plasma Level of Stem Cell Factor/c-kit and High Blood Pressure

作　　者：钟海兰[1] 卢新政[1] 陈秀梅[1] 杨晓慧[1] 王力 张海锋[1] 郑祖刚[3] 曹克将[1] 黄峻[1] 

机构地区：[1]南京医科大学第一附属医院心内科,江苏南京210029 [2]南京梅山医院心脏科,江苏南京210000 [3]江苏省中医院体检中心,江苏南京210000

出　　处：《中华高血压杂志》2009年第7期599-603,共5页Chinese Journal of Hypertension

摘　　要：背景高血压及血压升高导致的血管损伤在人群中患病率很高,干细胞因子(SCF)及其受体在血管损伤修复方面有重要作用。SCF可分两型,可溶型SCF参与各种病理应激反应,膜结合型与慢性炎症时血管形成和纤维化有关。目的探讨外周血浆中干细胞因子(SCF)及其受体(c-kit)表达与血压水平之间的关系。方法采用横断面研究方法,随机入选156例作为研究对象,包括正常血压(n=36),高血压前期(n=45)和高血压病人(n=75)。测量腰围、血压、血脂、血糖等指标。用酶联免疫吸附法(ELISA)检测外周血浆中SCF及其受体蛋白的表达,放射免疫法检测内皮素1及肿瘤坏死因子α(TNF-α)水平。结果①SCF及c-kit水平随血压水平的升高而增加[SCF:正常血压(768.8±44.1)比高血压前期:(834.6±47.6)比高血压:(907.1±52.3)ng/L;c-kit:正常血压(9.6±1.5)比高血压前期(11.1±2.1)比高血压(13.2±1.6)mg/L,P<0.01];②SCF及c-kit表达水平与收缩压、舒张压、内皮素1和TNF-α水平呈正相关;③多元线性回归显示SCF、c-kit和内皮素1是收缩压的危险因素,SCF、c-kit、内皮素1和TNF-α是舒张压的危险因素。结论外周血中SCF及其受体c-kit表达水平随血压水平升高而有逐渐升高趋势,并与收缩压、舒张压、内皮素1和TNF-α水平呈正相关,提示高血压病人血管有炎症过程,内皮明显损伤。Background Stem cell factor/c-kit are closely related to the repair of blood vessel injury and in- volved to the development of angiogenesis and tissue fibrosis. Objective This study evaluates the relationship between blood pressure and the expression of stem cell factor/c-kit in peripheral blood. Methods We performed a cross-sectional analysis of a cohort of 156 subjects, including normotensive （n =36 ）, prehypertension（n = 45 ） and hypertension（n=75）. Waist circumference, blood pressure, plasma glucose and serum lipids, plasma endothelin-1 and tumor necrosis factor-α were determined. Expression levels of stem cell factor and its receptor c-kit in peripheral blood were measured by ELISA. Results Plasma stem cell factor/c-kit was positively related to blood pressure levels ESCF： hypertension（907. 1±52.3） vs prehypertension （834.6±47. 6） vs normal control （768. 8±44. 1）ng/L; c-kit： hypertension （13.2±1.6） vs prehypertension （11.1±2. 1） vs normal control （9.6±1.5）mg/L, P〈0.01）. Stem cell factor/c-kit levels are also positively related to SBP, DBP, ET-1, TNF-α. Multiple linear regression showed that SCF, c-kit and ET-1 were independent predictors for systolic blood pressure; SCF, c-kit, ET-1 and TNF-α were independent predictors for diastolic blood pressure. Conclusion Stem cell factor/c-kit levels increased with blood pressure levels. Positive correlation between stem cell factor/c-kit levels and ET-1, TNF-α levels suggest hypertension was associated with vascular inflammation, endothelial dysfunction.

关 键 词：干细胞因子 于细胞因子受体 血压 内皮素1 肿瘤坏死因子Α 

分 类 号：R544.1[医药卫生—心血管疾病]