谷胱甘肽辅助治疗重型病毒性肝炎和肝炎肝硬化  

Adjuvant treatment of severe viral hepatitis and hepatitic cirrhosis with glutathione

作　　者：彭星亮[1] 蔡伊梅[1] 蔡伟[1] 郑皓琦 严振宜[1] 周霞秋[1] 

机构地区：[1]上海第二医科大学附属瑞金医院

出　　处：《中国新药与临床杂志》1998年第4期227-228,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的：探讨谷胱甘肽辅助治疗重型病毒性肝炎和肝炎肝硬化的疗效。方法：４０例病人分成２组，治疗组２０例（男性１６例，女性４例；年龄４４±ｓ１１ａ）在综合性治疗（用甘草酸二铵、肝细胞生长因子、茵栀黄等）基础上用谷胱甘肽０．６～１．２ｇ加入１０％葡萄糖注射液２５０ｍＬ中静脉滴注，ｑｄ，连续１～２ｍｏ。对照组２０例（男性１８例，女性２例；年龄４６±１２ａ）单用综合治疗。结果：治疗组症状、体征改善明显优于对照组（Ｐ＜０．０１，Ｐ＜０．０５）。总胆红素、凝血酶原时间变化亦优于对照组（Ｐ＜０．０５），但丙氨酸转氨酶治疗后２组间无明显差别（Ｐ＞０．０５）。结论：谷胱甘肽辅助治疗病毒性肝炎及肝炎肝硬化有较好的疗效。AIM: To estimate the adjuvant therapeutic efficacy of glutathione for severe viral hepatitis and hepatitic cirrhosis. METHODS: Forty patients were divided into two groups, treatment group with glutathione and control group. Twenty patients of treatment group (F 16, M4, age 44±s 11 a) were given 0.6_1.2 g glutathione in 250 mL 10% glucose, iv, gtt, qd, for 1_2 mo on the base of synthetic treatment with diammonii glycyrrhizinate, hepatic growth factor, Yin_zhi_huang etc. Twenty patients of control group (F 18, M 2, age 46±12 a) were given synthetic treatment. RESULTS: Improvements of symptoms and signs in treatment group were better than that in control group (P<0.01, P<0.05). The changes of serum bilirubin and prothrombin time in treatment group were superior to that in control group (P<0.05), but there was not significant difference of ALT change between treatment group and control group (P>0.05). CONCLUSION: adjuvant treatment of severe viral hepatitis and hepatitic cirrhosis with glutathione showed better therapeutic efficacy.

关 键 词：谷胱甘肽 病毒性肝炎 肝硬变 

分 类 号：R512.605[医药卫生—内科学] R575.205[医药卫生—临床医学]