血浆孤啡肽水平与心功能关系的初步研究  

An initial research of the relationship between plasma OFQ levels and heart function

作　　者：周秀娟[1] 桂鸣[1] 党瑜华[2] 唐朝枢[3] 石湘芸[4] 

机构地区：[1]南京医科大学第一附属医院老年医学科,210029 [2]河南医科大学第一附属医院心内科 [3]北京医科大学心血管基础研究所 [4]海军总医院心内科

出　　处：《江苏医药》1998年第8期550-552,共3页Jiangsu Medical Journal

摘　　要：为探讨充血性心力衰竭(CHF)患者血浆孤啡肽(OFQ)变化的临床意义,用放射免疫法测定了35例CHF患者和26例健康人血浆OFQ含量。结果表明:CHF患者血浆OFQ水平明显增高(16.20±0.87ng/L),较对照组(8.19±0.43ng/L)增加了约2倍(P<0.001);血浆OFQ含量与引起CHF的病因无关,而与CHF严重程度相平行,并发现与左室射血分数(LVEF)呈显著负相关(r=-0.84,P<0.001)。14例CHF患者经治疗好转后血浆OFQ含量下降(由15.96±1.43ng/L降至10.15±0.54ng/L,P<0.001)。提示OFQ在CHF的发病过程中可能具有一定作用。Plasma orphanin FQ(OFQ) was measured by radioimmunoassay in 35 patients with Congestive heart failure (CHF) and 26 healthy control subjects. The results showed that plasma OFQ levels were elevated in patients with CHF compared with control subjects (16.20±0.87ng/L vs 8.19±0. 43ng/L,.P<0. 001). There was no obvious relation between the plasma OFQ levels and the causes of heart failure, but there was a close relationship between the severity of CHF and the plasma OFQ levels. The severer the CHF, the higher the OFQ Level. Left ventricular ejection fraction was inversely correlated with the plasma OFQ levels (r=-0. 84,P<0. 001). The plasma OFQ levels of 14 of the 35 patients were significantly decreased as symptoms improved after treatment (from 15.96±1.43ng/L to 10.15±0.54ng/L,P<0. 001). These results suggest that OFQ might play a certain role in the pathophysiology of CHF.

关 键 词：充血性心力衰竭 孤啡肽 放射免疫测定法 

分 类 号：R541.61[医药卫生—心血管疾病]