壳聚糖在黏膜免疫中的应用  

The applications of chitosan in mucosal immunization

作　　者：曹斌[1] 张艳[1] 

机构地区：[1]湖南衡阳南华大学病原生物学研究所,421001

出　　处：《国际免疫学杂志》2009年第4期278-281,共4页International Journal of Immunology

基　　金：湖南省自然科学基金课题（06JJ2093）;湖南省教育厅青年基金课题（08B067）

摘　　要：目的黏膜免疫可以诱导有效的黏膜和系统免疫反应，从而保护黏膜表面，是防止病原体在黏膜表面克隆并入侵的关键。但黏膜接种疫苗吸收效率低，黏膜免疫效果往往不理想，因此需要添加有效的黏膜免疫佐剂和载体系统来提高疫苗的效果。壳聚糖是一种被广泛应用的天然聚合物，无毒，具有生物粘附性和免疫调节作用，在黏膜免疫中作为佐剂和载体得到大量应用。Mucosal immunity can effectively induce both mucosal and systemic immune responses to protect mucosa against pathogens. In general, vaccines alone are not sufficiently taken up after mucosal administration and result in poor immune responses. Therefore, adjuvant/delivery systems are required to enhance the immune response. Chitosan is a natural polymer which exerts advantages as a adjuvant or vaccine carrier due to its bioadhesive properties and immune-modulating activity. This review article focuses on mucosal immunization and chitosan as the mucosal vaccine adjuvant and carrier.

关 键 词：壳聚糖 黏膜免疫 核酸疫苗 

分 类 号：R392[医药卫生—免疫学]