纤维肌痛综合征疼痛机制的研究进展  

The progress on the pain mechanism of fibromyaigia syndrome

作　　者：张维[1] 刘传圣[1] 

机构地区：[1]青岛大学医学院附属医院疼痛诊疗科,266003

出　　处：《国际免疫学杂志》2009年第4期310-313,共4页International Journal of Immunology

摘　　要：纤维肌痛综合征（FMS）是风湿病门诊中的常见病，其疼痛的病因、发病机制尚未完全阐明。最新的研究热点集中于中枢神经系统疼痛传导通路的异常，如中枢致敏和疼痛抑制不充分等。外周组织伤害性传入刺激也作为相关因素引发和／或维持中枢致敏状态，同时神经内分泌和应激反应异常在FMS发病中也起重要作用。Fibromyalgia Syndrome（FMS） is a common disease in the rheumatison out-patient clinics Its pathogenesis is poorly understood. The latest studies have concentrated on the role of central nervous systerm pain processing abnormalities in FMS, including central sensitization and inadequate pain inhibition. The afference nociceptive stimulus from peripheral tissu as relevant contributor might either initiate or maintain central sensiti- zation, or both. Meanwhile, abnormalities of neuroendocrine and stress reaction also significantly affect the pathogenesis of FMS.

关 键 词：纤维肌痛综合征 致病机制 中枢致敏 神经内分泌 伤害性感受器 

分 类 号：R402[医药卫生—临床医学]