慢性阻塞性肺病患者肺循环动力学的动态变化  

Pulmono hemodynamic changes before and after exercise in chronic obstructive pulmonary disease

作　　者：郑翠霞[1] 徐凤珍 王爱华 刘玉珠 

机构地区：[1]蚌埠医学院附属医院肺科

出　　处：《蚌埠医学院学报》1998年第4期211-213,共3页Journal of Bengbu Medical College

摘　　要：目的：探讨运动试验对慢性阻塞性肺病（ＣＯＰＤ）患者并发肺心病的早期诊断价值。方法：ＣＯＰＤ组２０例和健康对照组２０名进行运动肺功能测试，运动前后分别测定平均肺动脉压（ｍＰＡＰ）、肺循环阻力（ＰＶＲ）及心排指数（ＣＩ）等（阻抗法）。结果：运动前两组肺循环动力学参数无差异。运动后，ＣＯＰＤ组的ｍＰＡＰ、ＰＶＲ均显著增高（Ｐ＜０．０１），ＣＩ无明显变化；对照组ｍＰＡＰ、ＰＶＲ下降，ＣＩ增加（Ｐ均＜０．０５）。结论：慢性阻塞性肺病患者运动中肺循环代偿反应能力下降，运动时右心负荷加重；运动前后动态观察肺循环动力学变化对ＣＯＰＤ并发肺心病的早期诊断有重要意义。Objective:To study the role of exercise test in early diagnosis of chronic obstructive pulmonary disease(COPD) with cor pulmonale.Methods:Pulmono hemodynamic indices were measured before and after incremental cycle exercise in 20 patients with COPD(16 male,4 female,mean age 60.2±7.1) and 20 healthy controls(16 male,4 female,mean age 57.6±6.4).Results:Before exercise,the mean pulmonary artery pressure(mPAP),pulmonary vessel resistance (PVR),and cardiac index(CI) were similar in both groups.After exercise,in COPD group,mPAP and PVR rose significantly( P <0.01) with no change in CI,in control group,mPAP and PVR lowered and CI increased significantly( P <0.05).Two cases of latent pulmonary arterial hypertension were found to have post exercise mPAP>3.59 kPa.Conclusions:Exercise test combined with pulmono hemodynamics measurement is of great value in early diagnosis of cor pulmonale.

关 键 词：肺疾病 阻塞性肺疾病 肺循环 运动试验 

分 类 号：R563[医药卫生—呼吸系统] R332.2[医药卫生—内科学]