儿童青少年肥胖与神经肽Y第二受体基因多态性  

Association between obesity and the polymorphism of neuropeptide Y2 receptor gene in children and adolescents

作　　者：张饭[1] 王海俊[2] 马军[1] 

机构地区：[1]北京大学公共卫生学院/儿童青少年卫生研究所,100191 [2]北京大学公共卫生学院妇女与儿童青少年卫生学系,100191

出　　处：《中华流行病学杂志》2009年第7期695-698,共4页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（30700668）;教育部留学回国人员科研启动基金;科技部“973”项目（2006CB503900）

摘　　要：目的探讨儿童青少年肥胖与神经肽Y第二受体（NPY2R）基因rs1047214多态性的相关性，及其与代谢综合征的关系。方法选择北京市2030名7～18岁的中小学生进行身体测量、血液生化指标测定和rs1047214多态性检测。结果NPY2R基因rs1047214多态性的等位基因突变率（T〉C）为18．6％；非肥胖组的纯合突变CC基因型频率为3．7％，明显高于肥胖组（1．7％，P〈0．05）；不同基因型BMI、腰围、腰臀比和腰围身高比水平的差异有统计学意义（P〈0．05），CC基因型低于非纯合突变型，性别分析显示男性差异有统计学意义；但是，采用多元线性回归分析方法，用BMI调整后，不同基因型腰围、腰臀比和腰围身高比水平的差异无统计学意义（P〉0．05）；不同基因型的血脂、血压、血糖指标水平的差异无统计学意义。结论儿童青少年NPY2R基因rs1047214多态性的突变率与男性肥胖有关，但与血脂、血压、血糖异常可能没有显著关联。Objective To study the relationship between neuropeptide Y2 receptor（NPY2R） gene rs1047214 polymorphism and obesity or metabolic syndrome in Chinese children and adolescents, in order to provide theoretical evidence for obesity control. Methods 2030 students at the age from 7 to 18 years were selected in Beijing. Physical indicators, blood pressure, serum lipids and fasting blood glucose and the rs1047214 polymorphism in NPY2R gene were tested for all the subjects. Results The mutation rate of the rs1047214 polymorphism （T〉C） was 18.6% and the CC genotype frequency was significantly higher in non-obese subjects （3.7%） than that in obese subjects （1.7%） （P〈0.05）. The differences of BMI, waist circumference （WC） , waist-hip ratio （WHR） and waist-to-height ratio （WtHR） were statistically significant among the subjects with CC genotype having lower BMI, WC, WHR and WtHR than CT＋TTcarriers （P〈0.05）, shown in males, but not in females. There were no statistical significances for WC, WHR or WtHR levels between different genotypes under the general linear regression model, after adjusted for BMI. There were no statistical significances for blood pressure, serum lipids and FPG level between different genotypes. Conclusion The mutation rate of the rs 1047214 polymorphism in NPY2R gene in Chinese adolescents was higher than that in foreign populations. Polymorphism seemed to be associated with obesity in males but did not seem to have significant association between polymorphism and other phenotypes of metabolic syndrome.

关 键 词：神经肽Y第二受体 基因多态性 肥胖 儿童青少年 

分 类 号：R681.02[医药卫生—骨科学] R544.1[医药卫生—外科学]