EGFR在妊娠期高血压疾病胎盘组织中的研究  

Study the role of EGFR in placental of hypertensive disorder complicating pregnancy

作　　者：朱慧英[1] 江朵[1] 任军[2] 

机构地区：[1]广东省深圳市龙岗区人民医院妇产科,518172 [2]广东省深圳市龙岗区人民医院外二科,518172

出　　处：《中国优生与遗传杂志》2009年第7期24-25,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨在妊娠期高血压疾病患者胎盘组织中表皮生长因子受体(EGFR)的表达与病因关系。方法通过免疫组织化学方法检测妊娠期高血压疾病患者64例(妊娠期高血压组21例,子痫前期轻度组23例,重度组20例)及健康足月孕妇20例(对照组)胎盘组织中EGFR蛋白的表达情况。结果妊娠期高血压疾病患者胎盘组织中表皮生长因子受体(EGFR)在妊娠期高血压组表达水平为56.174±3.1020,子痫前期轻度组患者中为78.6844±2.6713,两组比较,差异有统计学意义(t=18.73,P=0.0001);EGFR在子痫前期重度组患者中表达为94.2090±6.8352,与子痫前期轻度组比较,差异有统计学意义(t=11.37,P<0.0001)。结论妊娠期高血压疾病患者胎盘组织中EGFR的蛋白表达升高和过度激活,可能在妊娠期高血压疾病发生发展中起重要作用。Objective： To study the role of EGFR in hypertensive disorder complicating pregnancy. Methods： Immunohistochemistry used to investigate the expression of EGFR proteins in placental from gestational hypertension, mild preeclampsia, severe preeclampsia and normal term pregnant women. Results ： Expression of EGFR proteins level in placenta of mild preeclampsia higher than that gestational hypertension （ P = 0. 0001 ）. Expression of EGFR proteins in placenta of severe preeelampsiawas significantly higher than that mild preeelampsia, P 〈 0. 0001. Conclusion： It suggested that abnormal proteins expressions and activation of EGFR may play important roles in the placental of hypertensive disorder complicating pregnancy.

关 键 词：妊娠期高血压疾病 表皮生长因子受体 胎盘 

分 类 号：R714.246[医药卫生—妇产科学]