复方苦参注射液联合头颈部放疗的临床观察  

Clinical Efficacy of Compound Radix Sophorae Flavescentis Injection plus Radiotherapy of Head and Neck

作　　者：钟敏钰[1] 胡作为[1] 孙忠义[1] 明国联[1] 刘文杰[1] 蔡煜[1] 叶希[1] 

机构地区：[1]武汉市第一医院,武汉市430022

出　　处：《中国医院用药评价与分析》2009年第6期462-464,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察联用复方苦参注射液在头颈部放疗中的作用。方法:应用复方苦参注射液配合头颈部放疗32例与单纯放疗32例对照。结果:研究组总的放疗2～4级急性损伤发生率明显低于对照组(P<0.005),其中白细胞、皮肤、黏膜、咽和食管的放疗2～4级急性损伤发生率明显降低(P<0.000 1～0.01);中、重度疼痛发生率研究组明显低于对照组(P<0.005);加用苦参后放疗对患者生活质量影响较小(P<0.05),并可促进生活质量的恢复(P=0.02<0.05);以上差异均有统计学意义。结论:头颈部放疗时联合复方苦参注射液可见明显减低放疗不良反应,减少放疗对患者生活质量的影响。OBJECTIVE： To evaluate the efficacy of Compound Radix Sophorae Flavescentis Injection plus radiotherapy for patients with cancers of head and neck. METHODS： 64 cases with cancers of head and neck were assigned to receive radiotherapy plus Compound Radix Sophorae Flavescentis Injection （trial group, n = 32） or radiotherapy alone （control group, n = 32）. RESULTS： The total incidence rate of 2 - 4 grade acute radiation injury in the trial group was significantly lower than in the control group （ P 〈 0.005 ）, much as in the injury of while blood cell, skin, mucous, pharynx and esophagus （P 〈 0.000 1 - 0.01 ）. The incidence rates of intermediate and severe pain in the trial group was also significantly lower than in control group （P 〈 0.005）. The addition of Compound Radix Sophorae Flavescentis Injection to radiotherapy attenuated the negative impact of radiotherapy on patients＇ life quality （ P 〈 0.05 ） and contributed to the recovery of quality of life （P = 0.02 〈 0.05）, all showing significantly differences. CONCLUSION： The addition of Compound Radix Sophorae Flavescentis Injection to radiotherapy can attenuate the toxicity of radiotherapy and attenuate the impact of radiotherapy on patients＇ life quality.

关 键 词：复方苦参注射液 头颈部肿瘤 放疗 

分 类 号：R979.1[医药卫生—药品]