拉莫三嗪治疗脑损伤后脑水肿的实验研究  

Effect of Lamotrigine on Cerebral Edema Following Traumatic Brain Injury in Rats

作　　者：程远[1,2,3] 陈复仁[1,2,3] 吴泳 张晓萍[1,2,3] 

机构地区：[1]重庆医科大学第二临床医学院神经外科 [2]成都妇幼保健院 [3]重庆医科大学基础医学院中心实验室

出　　处：《中华创伤杂志》1998年第4期209-211,共3页Chinese Journal of Trauma

摘　　要：目的通过大鼠脑冲击伤模型，观察脑损伤后兴奋性氨基酸谷氨酸变化规律以及拉莫三嗪对急性脑水肿的治疗效果，并探讨其作用机制。方法采用干湿重法，微透析技术及氨基酸分析测定脑损伤后不同区域，不同时相脑组织的水含量及谷氨酸的浓度。结果（１）脑损伤组脑组织的水含量，细胞外液谷氨酸浓度明显高于对照组；（２）脑损伤组损伤区域的脑水肿和细胞外液谷氨酸呈自身扩播性；（３）拉莫三嗪治疗组脑组织含水量以及谷氨酸浓度明显低于脑损伤非治疗组。Aim To investigate the effect of lamotrigine (LTG) on cerebral edema following traumatic brain injury, and to discuss the mechanism. Methods This study was done on the experimental animal models (rats) with impacted brain injury. The change of water content in brain was measured with “dryingwet” method, and the change of glutamate was measured with microdialysis technique and amino acids automaticanalyzes. Results (1) The water content and glutamate in the injured brain were significantly greater than those in the control group. (2) In the injured brain, the contents of water and glutamate showed a selfdiffusion process. (3) The contents of water and glutamate in the LTGtreated group were significantly lower than those in the nontreated group. Conclusion LTG can deal with cerebral edema by inhibiting neurons to release glutamate.

关 键 词：颅脑损伤 脑水肿 拉莫三嗪 药物疗法 

分 类 号：R651.150.5[医药卫生—外科学]