大剂量激素对脑创伤家兔脑微循环及血液流变性的影响  

Effects of High-Dose Dexamethasone on Cerebral Microcirculation and Hemorheology in Rabbits with Cerebral Trauma

作　　者：陈治标[1] 张宇兰[1] 马珍梅[1] 叶应湖[1] 王国安[1] 

机构地区：[1]湖北医科大学附属第一医院

出　　处：《微循环学杂志》1998年第2期10-12,共3页Chinese Journal of Microcirculation

摘　　要：为探讨大剂量激素对脑创伤后脑微循环及血液流变性的影响，将２４只家兔随机等分为３组：标准对照组、损伤对照组和地塞米松治疗组。分别在伤前０．５ｈ、伤后０．５ｈ、１ｈ、２ｈ、３ｈ测量软脑膜微动脉管径和血流速度的变化及伤后３ｈ血液流变学指标。结果表明：大剂量激素在伤后０．５ｈ就能明显地扩张损伤处软脑膜的微动脉并使血流速度明显加快。伤后３ｈ能明显降低血沉、全血粘度、红细胞压积及纤维蛋白原含量，并明显增强红细胞的变形能力，降低其聚集性。To understand the effects of high-dose dexamethasone on pia mater microcirculation and hemorheology,24 rabbits were randomly divided into 3 groups:standard group, the trauma group and the dexamethasone treatment group.Parameters about pia mater microcirculation and hemorheology were measured at different interval.The results showed that high-dose dexamethasone had significant role of extending pia mater microartery,increasing pia mater blood flow-rate,reducing whole blood viscosity,erythrocyte aggregation,ESR,HCT,and increasing erythrocyte deformability.The results suggest that high-dose dexamethasone can improve cerebral microcirculation and hemorheology in rabbits with cerebral trauma.

关 键 词：激素 脑创伤 血液流变学 微循环 

分 类 号：R651.150.5[医药卫生—外科学] R977.1[医药卫生—临床医学]