新型有机-无机杂化陶瓷型脂质体“Cerasome”的研究与应用  

Research Progress and Application of Novel Class of Organic-Inorganic Hybridized Liposome "Cerasome"

作　　者：李纪龙[1,2] 王剑锋[2] 范圣第[2] 

机构地区：[1]大连理工大学环境与生命学院生物科学与工程系,大连116024 [2]大连民族学院生命科学学院生物技术与资源利用国家民委-教育部重点实验室,大连116600

出　　处：《材料导报》2009年第13期50-53,共4页Materials Reports

基　　金：国家自然科学基金资助项目(20472013)

摘　　要：Cerasome是20世纪90年代末制备出来的一种新型有机-无机杂化的陶瓷型脂质体,与传统的脂质体相比,它的表面覆盖了一层硅酸盐网络结构,因而兼具有机和无机性质。无机硅酸盐的网络结构使它具有良好的形态稳定性,克服了传统脂质体在这方面存在的巨大缺陷。综述了形成Cerasome的前体化合物、Cerasome的制备及性质,对其在三维纳米杂化体构建、新型磁性杂化材料的制作、基因转染载体以及生物膜模拟等领域的研究进行了的评述,并对Cerasome未来的研究发展趋势进行了展望。A novel class of organic-inorganic hybrid material called ＂Cerasome＂ which is a ceramic-coated liposome, was prepared in the 1990＇s. Compared to conventional liposome, it is characterized with both organic and inorganic properties due to the silicate framework covered on its surface. Thus, Cerasome remains its morphological stability and overcomes enormous defect in the conventional liposome. In this paper, the Cerasome-forming precursor compound, the preparation for Cerasome and its properties are summarized, and its applications in three-dimensional hybrid material, novel magnetic material, gene transfection carrier and biomimetic membrane are reviewed. Finally, the study on Cerasome in the future is prospected.

关 键 词：脂质体 有机-无机杂化体 硅酸盐网络 三维杂化材料 磁性材料 

分 类 号：TQ314.253[化学工程—高聚物工业] TQ460.4