L-[S-^(11)C-甲基]-蛋氨酸的合成研究  

Automated Synthesis Of (S-[^(11)C]-Methyl)-L-Methionine

作　　者：彭添兴[1] 范文博[1] 颜和平[1] 

机构地区：[1]福建医科大学附属厦门第一医院核医学科,厦门361003

出　　处：《化工文摘》2009年第4期28-29,32,共3页

摘　　要：由MINItrace回旋加速器通过核反应14N(p,α)11C生产11CO2,经甲烷循环碘化法和11CH3I全自动合成系统制备11CH3I。采用11C-MET全自动合成装置,11CH3I与前体的碱性溶液反应得到11C-MET注射液。合成时间为60min,放化产率大于10%,放化纯度大于99%。^11CO2 was produced via nuclear reaction ^14N（p, α）^11C at MINItrace Cyclotron, then ^11CH3I was prepared with uncorrected radiochemical by the recycle iodination of.[^11C]methane at ^11CH3I MicroLab Process Module. ^11C-MET was synthesized from [^11C]methylation of ^11CH3I with precursor. The radiochemical yield of [^11C]methylation was more than 10% with the synthesis time about 60 rain and the radiochemical purity of ^11C-MET was above 99%.

关 键 词：全自动合成 11C-MET 液相反应 

分 类 号：TQ223.121[化学工程—有机化工] S831.5[农业科学—畜牧学]