前列地尔固体脂质纳米粒的制备及质量评价  

Preparation and Quality Evaluation of Alprostadil Solid Lipid Nanoparticles

作　　者：邹姜甫[1] 顾王文[2] 李亚平[1,2] 陈伶俐[2] 

机构地区：[1]江苏大学药学院,江苏镇江212013 [2]中国科学院上海药物研究所药物释放系统研究中心,上海201203

出　　处：《中国医药工业杂志》2009年第7期495-499,共5页Chinese Journal of Pharmaceuticals

摘　　要：采用薄膜分散法结合高压匀质技术和冷冻干燥工艺制备前列地尔固体脂质纳米粒。测得其平均粒径为(137.2±7.7)nm,包封率大于90%。在磷酸盐缓冲液(pH7.4)中24h累积释放率为43.6%。产品于(4±2)℃和(25±2)℃下保存6个月稳定性良好。The alprostadil solid lipid nanoparticles （SLN） were prepared by film dispersing method and followed by high pressure homogenization and lyophilization. The mean particle size of the alprostadil SLN was （137.2± 7.7） nm and the entrapment efficiency was above 90 %. The in vitro release test showed that accumulative release at 24 h was 43.6% in phosphate buffer （pH 7.4） and the release curve was fitted with Weibull equation. No significant changes were measured after the aiprostadil SLN were stored at （4±2） ℃ and （25±2） ℃ for six monthes.

关 键 词：前列地尔 固体脂质纳米粒 薄膜分散法 冷冻干燥 包封率 

分 类 号：R944.9[医药卫生—药剂学]