一种新型可生物降解聚酯的合成与性能研究  

Study on synthesis and properties of a novel biodegradable polyester

作　　者：徐亚鹏 倪忠斌 李继航 陈明清 任静娇 李会玲 

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122

出　　处：《应用化工》2009年第6期795-798,802,共5页Applied Chemical Industry

基　　金：国家自然科学基金项目(20876070);江苏高等学校科技创新团队资助项目(苏教科[2007]5号)

摘　　要：使来源于天然植物的3,4-二羟基肉桂酸（DHCA）和对羟基苯甲酸（HA）进行熔融缩聚,制得了新型聚酯（PDHCA-co-PHA）,用核磁共振、傅立叶红外光谱和凝胶渗透色谱对PDHCA-co-PHA的结构与相对分子量进行分析表明,所合成的共聚物结构明确。通过差示扫描量热和X-射线衍射对共聚物的热性能与结晶性能的研究表明,PDHCAc-o-PHA的玻璃化转变温度随着HA投料量的增加而降低;PDHCA-co-PHA为无定形结构聚合物,有利于生物降解。通过三氟乙酸与N,N-二甲基甲酰胺的离子化作用,制备了PDHCAc-o-PHA共聚物微球,微球粒径在1~2μm之间可用于药物负载等领域。Poly （ 3,4-dihydroxycinnamic acid ） -co-poly （p-hydroxybenzoic acid ） （PDHCA-co-PHA） co- polymers were synthesized by thermal polycondensation between 3,4-dihydroxycinnamic acid （DHCA） and p-hydroxybenzoic （HA）. The structures and molecular weight of PDHCA-co-PHA copolymers were characterized by 1H-NMR, FTIR and GPC. The properties of the polyester were investigated by DSC and X-ray diffraction. The result showed that glass transition temperature （ Tg） of PDHCA-co-PHA decreased when HA feeding increased. The XRD results indicated that PDHCA and PDHCA-co-PHA are amorphous and these polymers may have good biodegradation performance. Mierospheres were prepared by solvent transformation in ionic liquids between trifluoroacetic acid （TFA） and N,N-dimethylform amide（DMF）. The sizes of these microspheres were between 1 -2 um and they could be used in drug delivery areas.

关 键 词：3 4-二羟基肉桂酸 对羟基苯甲酸 生物降解性 高分子微球 

分 类 号：O63[理学—高分子化学]