慢性乙肝患者肝纤维化乙肝病毒复制水平的检测  

HBV virus replication level test in patients with chronic hepatitis B in the liver fibrosis stage

作　　者：白云贤[1] 姜平[1] 孙永福[1] 郭学茹[1] 郝颖萍[1] 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001

出　　处：《宁夏医学杂志》2009年第7期613-614,共2页Ningxia Medical Journal

摘　　要：目的探讨慢性乙肝患者肝组织纤维化与乙型肝炎病毒复制水平之间的关系。方法按HBV-DNA检测,分为阴性组94例、阳性组86例,采用核酸扩增荧光定量(FQ-PCR)检测HBV-DNA,放射免疫分析(RIA)检测肝纤维化标志物肝胆酸(CG)、透明质酸(HA)、Ⅲ型前胶原肽(PCⅢ)、四型胶原(IV-C)和层黏连蛋白(LN)。结果慢性乙肝患者HBV-DNA复制水平增高,血清肝纤维化标志物含量亦增高(P<0.05,P<0.01)。结论慢性乙肝患者乙型肝炎病毒复制水平增高可促使肝组织纤维化,抗病毒治疗、清除和控制病毒复制对阻止肝组织纤维化有益。Objective To investigate the relationship between liver fibrosis stage and HBV virus replication level in patients with chronic hepatitis B. Methods HBV - DNA were measured by the way of nucleic acid amplification fluorescent quantitation （ FQ - PCR） and serum liver fibrosis markers such as CG, HA, PCⅢ, Ⅳ - C and LN were detected by the way of radioimmunoassay （RIA）. Results The contents of serum liver fibrosis markers were elected on the level of HBV - DNA replication. Conclusion The higher level of HBV virus replication will accelerate liver fibrosis in patients with chronic hepatitis. To control and clear HBV virus replication is beneficial to stopping liver fibrosis.

关 键 词：慢性乙肝 HBV—DNA复制 肝纤维化 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学] R450