硅微通道红细胞变形性测量系统的实用化研究  

Study on practicality of micro-channel measurement system for red blood cell deformability

作　　者：郑小林[1,2] 常婧[1] 廖彦剑[1] 杨军[1] 刘畅[1] 

机构地区：[1]重庆大学生物工程学院,重庆400030 [2]新型微纳器件与系统技术国家重点学科实验室,重庆400044

出　　处：《传感器与微系统》2009年第7期117-120,共4页Transducer and Microsystem Technologies

基　　金：重庆市自然科学基金资助项目(CTST2007BB5165);重庆市"十一五"科技重大专项基金资助项目(CSTC2008AA5010);国家高技术研究发展计划资助项目(2006AA04Z343);国家自然科学基金资助项目(30870661;30770569;30500120)

摘　　要：针对硅微通道红细胞变形性测量系统的实用化关键性技术,包括小型化、集成化和操作的规范性、简便性等方面进行研究。利用聚二甲基硅氧烷(PDMS)进行芯片和流路接口的一次性封装,使芯片测量部分整体成型。另外,将系统的进样驱动改进为恒流源,采用注射泵控制,使系统更易实现,且提高了进样的稳定性。针对改进系统的初步实验表明:恒流驱动具有良好的稳定性,在一定程度上更接近人体微循环毛细血管环境,系统操作简便,增加了红细胞变形性分析的可靠性。The critical technology related to the practicality of micro-channel measurement system for red blood cell（ RBC ） deformability is investigated, in terms of miniaturization, integration, especially the normative and convenient operation. Two improvements are made on the system. The original silicon chip and the flow paths are packaged in a single chip by the use of PDMS to realize the plug and play function. The injection pump is used for the sampling and flow driving to improve the stability of sample injection. The preliminary experiment results show that the system in the constant flow driving mode is more stable, more suitable to simulate the Human capillary microcirculation environment and more reliable for analysis of red blood cell deformability.

关 键 词：硅微通道 红细胞变形性 聚二甲基硅氧烷 

分 类 号：R318.01[医药卫生—生物医学工程]