正交试验法优选前列宁颗粒剂的提取工艺  

Optimization of the Extraction Process of Qianliening Granules by Orthogonal Test

作　　者：徐伟[1] 周建衡[1] 洪振丰[1] 郑海音[1] 黄晓薇[1] 

机构地区：[1]福建中医学院,福州350108

出　　处：《浙江中医药大学学报》2009年第4期579-581,共3页Journal of Zhejiang Chinese Medical University

基　　金：福建省科技厅重点项目(No:2008Y0049);福建省中西医结合老年病疾病重点实验室及陈可冀中西医结合发展基金(No:2008J1004-17CKJ2008054)~~

摘　　要：[目的]筛选和优化前列宁颗粒剂提取工艺。[方法]采用正交设计法,以水醇两组提取物中浸膏得率、有效成分分别为大黄酸和黄芪甲苷提取率为指标,确定提取参数。[结果]确定黄芪等药组水提工艺为10倍量水,煎煮3次,每次1.5h;大黄等药醇提组工艺为6倍量60%乙醇,提取2次,分别为2.0、1.5h。[结论]前列宁颗粒剂提取工艺稳定,可行。[Objective]To filter and optimize extractive technology of Qianliening granules. [Methods]The optimization extractive technology of Qianliening granules was investigated using orthogonal design with the availability component extracting from the drug as the index. [Results]The optimal condition for the extraction of Radix Astragali group was 10 folds amount of water, 3 times, 1.5 hours each time. The optimal condition for the extraction of Rheum officinal Baill. group was 6 folds amount of 60% alcohol,2 times,two hours and 1.5 hours each time. [Conclusion]The optimized extractive technology is scientific and efficient.

关 键 词：前列宁颗粒剂 大黄酸 黄芪甲苷 提取工艺 正交设计 

分 类 号：R284.2[医药卫生—中药学]