镇静安神类中成药及保健食品中非法添加化学成分的快速筛查方法研究  

Fast detection of sedative-hypnotic drugs in traditional Chinese medicines and health foods by TLC

作　　者：肖丽和[1] 刘吉金[1] 关潇滢[1] 熊英[1] 王铁杰[1] 李军[1] 

机构地区：[1]深圳市药品检验所,广东深圳518029

出　　处：《中国当代医药》2009年第14期15-16,共2页China Modern Medicine

摘　　要：目的:建立镇静安神类中成药及保健食品中非法添加的地西泮等14种化学成分的薄层色谱快速检测方法。方法:样品经甲醇提取后点于硅胶GF254薄层板上;以二氯甲烷-甲苯-丙酮-甲醇(8∶8∶3∶1)为展开剂,检测地西泮等10种苯并二氮杂卓类添加成分;以正庚烷-甲苯-丙酮-三乙胺(6∶5∶4∶1)为展开剂,检测巴比妥等4种巴比妥类添加成分;展开后置紫外光灯(254nm)下检视。结果:在选定的色谱条件下,14种化学成分能得到较好的分离。结论:本法快速、简便,可作为镇静安神类中成药及保健食品中非法添加地西泮等14种化学成分的快速筛查方法。Objective：To establish a TLC method for detection of 14 sedative-hypnotic drugs in traditional Chinese medicines and health foods. Methods：Use silica gel GF254 as the coating substance,dichloromethane-toluene-acetone-methanol （8：8：3：1） as the mobile phase system I to detect 10 barbiturates and n-heptane-toluene-acetone-triethylamine （6： 5：4：1） as the mobile phase system 11 to detect 4 benzodiazepines. Results：At the selected chromatographic conditions,14 kinds of chemical constituents could get a better separation. Conclusion：The method is convenient, rapid, exclusive and can be employed to the fast detection Of sedative-hypnotic drugs in traditional Chinese medicines and health foods.

关 键 词：镇静催眠药物 快速检测 TLC 

分 类 号：R965.1[医药卫生—药理学]