口服奥美沙坦酯对SHR延髓腹外侧头端注射AngⅡ引起动脉压心率变化的影响  

EFFECT OF ORAL ADMINISTRATION OF OLMESARTAN ON THE ARTERIAL PRESSURE AND HEART RATE RESPONSE TO MICROINJECTION ANGII IN THE ROSTRAL VENTROLATERAL MEDULLA OF SHR

作　　者：张旭[1] 王绍久[1] 林英子[1] 汪茜[2] 王一丁[2] 朱杰[1] 

机构地区：[1]中国医科大学附属第四医院,沈阳110032 [2]中国医科大学

出　　处：《现代预防医学》2009年第14期2768-2770,共3页Modern Preventive Medicine

基　　金：辽宁省教育厅高等学校科学技术研究项目(05L566)

摘　　要：[目的]探讨口服血管紧张素II1型受体阻滞剂(angiotensin II type 1 receptor blockade,ARB)奥美沙坦(olmesartan)对自发性高血压大鼠(spontaneously hypertensiverats,SHR)延髓腹外侧头端(rostral ventrolateral medulla,RVLM)局部肾素血管紧张素系统(rennin-angiotensin system,RAS)的影响。[方法]雄性12周龄SHR14只,随机分成SHR组(正常饮水,n=7)及SHR-Olme组(olmesartan,10μg/(g.day),n=7),WKY组为正常血压大鼠7只(olmesartan,10μg/(g.day),n=7)。喂养4周后在延髓腹外侧头端微量注射血管紧张素II(angiotensinII,AngII),观察平均动脉压(meanarterialpressure,MAP)和心率(heartrate,HR)的变化。[结果]AngII可使SHR组MAP明显升高(+14.1±4.6mmHg),SHR-Olme组轻度升高(+3.7±1.4mmHg,),2组比较差异有统计学意义(P﹤0.05),WKY组MAP升高不明显(+2.0±0.8mmHg),与SHR组及SHR-Olme组比较,差异有统计学意义(P﹤0.05);3组心率变化差异无统计学意义。[结论]奥美沙坦能通过影响脑组织局部肾素血管紧张素系统产生降压作用。[Objective] To investigate the central effect of oral administration of olmesartan （art AT1 receptor antagonist） on the rennin-angiotensin system in the Rostral ventrolateral medulla of spontaneously hypertensive rats. [ Methods] 14 male SHRs were randomly divided into SHR group （normal water, n=7） and SHR-Olme group （olmesartan in drinking water, 10μg/（g.day）, n=7）, age-matched wistar-Kyotorats （WKY） （olmesartan in drinking water, 10μg/（g.day）, n=7）.After fed for 4 weeks, microinject angiotensin II （AngII） in the rostral ventrolateral medulla, the changes of the mean arterial pressure and heart rate were observed. [ Results ] The pressor responses to microinjeetion of AngII in the Ohnesartantreated SHR （＋3.7±1.4mmHg） were significantly weaker than those in untreated SHR （＋14.1±4.6mmHg）; however, they were still greater than those in the Wistar-Kyoto rats （＋2.0±0.8mmHg, P 〈 0.05）; the changes in HR did not differ among the three groups. [Conclusion ] Olmesartan may partly normalize the arterial pressure by acting on the central rennin-angiotensin system.

关 键 词：奥美沙坦 血管紧张素Ⅱ 1型受体 自发性高血压大鼠 延髓腹外侧头端 

分 类 号：R972[医药卫生—药品]