高血压合并肥胖患者脉搏波传导速度的变化及其相关影响因素分析  

Analysis of Related Factors of Pulse Wave Velocity in Hypertensive Patients with Obesity

作　　者：李洁芳[1,2] 袁洪[1] 黄志军[1] 孙旭[1] 翁春艳[1] 陈志恒[3] 邓秀娟 杨娉婷[3] 

机构地区：[1]中南大学湘雅三医院心内科 [2]长沙市四医院 [3]中南大学湘雅三医院健康管理中心,湖南省长沙市410003

出　　处：《中国动脉硬化杂志》2009年第5期387-390,共4页Chinese Journal of Arteriosclerosis

基　　金：中央保健专项资金(169);湖南省卫生厅重点项目(A2007-004);中南大学米塔尔学生创新创业项目(07MX25)资助

摘　　要：目的探讨高血压合并肥胖患者脉搏波传导速度的变化及其相关影响因素。方法随机入选高血压合并肥胖患者和单纯高血压患者各300例。应用日本科林VP-1000动脉硬化测定仪测定臂踝脉搏波传导速度,同时检测血糖、甘油三酯、肌酐、尿酸、高密度脂蛋白胆固醇、总胆固醇及腰围等指标,并以臂踝脉搏波传导速度为因变量,以年龄、收缩压、舒张压、脉压、体质指数、腰围、血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、肌酐、尿酸等为自变量,行臂踝脉搏波传导速度的多因素分析。结果高血压合并肥胖患者臂踝脉搏波传导速度(1635±239cm/s)较单纯高血压患者(1583±288 cm/s)显著升高(P<0.05)。Pearson相关分析表明,两组臂踝脉搏波传导速度均与收缩压、脉压显著正相关(P<0.05),与舒张压无相关性(P>0.05)。多元逐步回归分析表明,600例高血压患者中年龄、收缩压和腰围与反映动脉僵硬度的臂踝脉搏波传导速度关系密切(P<0.05)。结论高血压合并肥胖患者与单纯高血压患者之间臂踝脉搏波传导速度存在显著性差异,年龄、收缩压及腰围与臂踝脉搏波传导速度相关。Aim To explore the changes and related factors of pulse wave velocity （PWV） in hypertensive patients with obesity. Methods 300 hypertensive subjects in each group with or without obesity were enrolled. Brachial-ankle PWV （baPWV） in each patient were measured by using VP-1000 measurement system, and their blood glucose, total cholesterol, triglyceride, high density hpoprotein cholesterol, low density lipoprotein cholesterol, uric acid and waist circumference were determined. With BaPWV as the dependent variable and age, systolic blood pressure, diastolic blood pressure, pulse pressure, body mass index, waist circumference, blood glucose, triglycerides, total cholesterol, high density lipoprotein, creatinine, uric acid as independent variables, the multivariate analysis was made. Results BaPWV was significantly higher in hypertensive with obesity group （ 1635±239 cm/s） than those in simple hypertensive group（1583±288 cm/s ; P 〈 0.05 ）. BaPWV was positively related to systolic blood pressure and pulse pressure （P 〈 0.05 ）, but not related to diastolic blood pressure （P 〉 0.05 ）. Multiple stepwise regression analysis showed that age, systolic blood pressure and waist circumference were closely related to baPWV as an arterial stiffness maker in the 600 hypertensive patients. Conclusions BaPWV has significant difference between hypertension complicated by obesity and simple hypertension. Age, systolic blood pressure and waist circumference are closely related to baPWV.

关 键 词：高血压病 肥胖 脉搏波传导速度 

分 类 号：R5[医药卫生—内科学]