N-苯基-2,2-二(4-氯苯氧基)乙酰胺的合成  

Synthesis of N-phenyl-2,2-di(4-chlorophenoxy)acetamide

作　　者：王红[1] 金东元[1] 高永红[1] 陶建伟[1] 

机构地区：[1]上海应用技术学院化学工程系,上海200235

出　　处：《化学试剂》2009年第7期561-562,564,共3页Chemical Reagents

基　　金：上海市教育委员会发展基金资助项目(050Z13)

摘　　要：在无水碳酸钾存在下,N,N-二甲基甲酰胺(DMF)为溶剂,由二氯乙酰氯和苯胺反应,制备了中间体N-苯基二氯乙酰胺。进而,中间体与4-氯苯酚反应,得到标题化合物。着重考察了反应温度、反应时间、物料物质的量比对目的产物收率的影响,确定了合成工艺条件为:反应温度80℃,反应时间4h,n(N-苯基-二氯乙酰胺):n(4-氯苯酚)=1.0:2.2,在此条件下,标题化合物的产率达75%以上。化合物的结构经IR、1HNMR、元素分析进行了表征。N-Phenyl-2, 2-di （ 4-chlorophenoxy ） acetamide was synthesized by the reaction of 4-chlorophenol on N-phenyl dichloroacetamide, which was prepared from dichloroacetyl chloride and aniline using tetrahydrofuran （THF） as the organic solvent in the presence of anhydrous potassium carbonate. The effect of feed composition,reaction temperature and reaction time on the yield of N-phenyl-2,2-di（4-chlorophenoxy）acetamide was investigated. The optimized conditions obtained were： a reaction temperature of 80 ℃, a reaction time of 4 h, and a ratio of （ N- phenyl dichloroacetamide）/（4-chlorophenol） = 1.0：2.2. The yield of N-phenyl-2, 2-di （ 4-chlorophenoxy ） acetamide could reach 75 %. The structure of the compound was characterized by IR, ^1HNMR and elemental analysis.

关 键 词：N-苯基二氯乙酰胺 N-苯基-2 2-二(4-氯苯氧基)乙酰胺 合成 

分 类 号：TQ225.261[化学工程—有机化工]