维库溴铵的合成工艺改进  

Improved synthesis of vecuronium bromide

作　　者：蒋虹[1] 顾菲[2] 屠树江[1,2] 冯友建[1] 

机构地区：[1]徐州师范大学江苏省药用植物生物技术重点实验室,江苏徐州221116 [2]徐州师范大学化学化工学院,江苏徐州221116

出　　处：《化学试剂》2009年第7期568-570,共3页Chemical Reagents

基　　金：徐州市科技局自然科学基金资助项目(XJ07066);江苏省大型科学仪器设备共享服务平台理事会资助项目;徐州师范大学自然科学研究基金资助项目(07XLB20)

摘　　要：以表雄酮为原料经磺酸酯化、消去、酯化、氧化、开环、还原、乙酰化,最后和溴甲烷成盐等8步反应合成维库溴铵,操作简捷、条件温和、成本低,适合工业化生产,产品结构经红外光谱、核磁共振谱、质谱确证,总收率19.6%。Vecuronium bromide was synthesized from epiandrosterone through esterification, elimination, oxidation, ring opening, reduction, and acetylation, followed by reaction with bromomethane. This cost-saving and simplified method can be used in the commercial scale manufacture. The structure of this product was elucidated by IR, ^1HNMR, ^13CNMR, DEPT and MS, with an overall product yield reaching 19.6%.

关 键 词：维库溴铵 肌松药 非去极化 合成 

分 类 号：O629[理学—有机化学]