同型半胱氨酸在冠状动脉粥样硬化性心脏病中的临床意义  

Homocysteine and it’s Clinical Significance in Coronary Artery Heart Disease

作　　者：孙轶然[1] 蔺瑞兰[2] 崔卫东[2] 

机构地区：[1]华中科技大学同济医学院药学院,武汉430030 [2]天津市宁河县医院检验科,天津301500

出　　处：《医学综述》2009年第15期2356-2357,共2页Medical Recapitulate

摘　　要：目的了解同型半胱氨酸（Hcy）与冠状动脉粥样硬化性心脏病（CHD）的严重程度及Hcy与CHD传统危险因素的相关性。方法利用循环酶法（enzymatic cycling assay）检测CHD患者（81例）和对照组（36例）血清中Hcy的水平。结果CHD组Hcy的含量明显高于对照组（P〈0．01），急性心肌梗死患者（AMD）Hcy含量〉不稳定性心绞痛者（UAP）〉稳定性心绞痛者（SAP）；两组有同一危险因素患者的Hcy的含量比较差异均有统计学意义（均P〈0．01）；两组内有传统危险因素与无危险因素患者之间Hcy的含量均无统计学意义（均P〉0．05）。结论高Hcy是CHD的独立危险因子，病情越重，Hcy的含量越高。Hcy-9CHD病变的发生、发展可能有直接关系。检测Hcy水平对预防和减低CHD的发生具有重要意义。Objective To debate the severity of homocysteine （Hcy） and coronary atherosclerotic heart disease（CHD）ass well as their associativity of risk factor related to Hcy and CHD. Methods Serum Hcy level in group of 36 cases with CHD and control group of 36 cases were detected by enzymatic cycling assay. Results CHD group had high concentration of Hcy than control group （ P 〈 0.01 ）. So did the Hey in patients with AMD than patients with UAP, as well as patients with UAP than patients with SAP（ P 〈 0.01 ）. There is great significance in Hcy consentration between two group with the same risk factors （P 〈0.01 ）. There is no statistic significance between two group with or without risk factors（ P 〉 0.05 ）. Conclusion Hcy is an independent risk factor for CHD,the more serious of condition,the higher of Hey levels. Hcy may have direct relationship with the genesis and development of CHD. Detecting the Hey level will have great significance in preventing and reducing the occurrence of CHD.

关 键 词：同型半胱氨酸 冠状动脉粥样硬化性心脏病 循环酶法 

分 类 号：R446.62[医药卫生—诊断学]